Gastrointestinal tone; its genesis and contribution to the physical processes of digestion

Lentle, Roger G.; Reynolds, Gordon; Janssen, Patrick

doi:10.1111/nmo.12223

Cited by 7 publications

(2 citation statements)

References 111 publications

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“…Soft fibrous tissues – e.g., ligaments, the heart, blood vessels, gastrointestinal tract and the urethra – perform functions which rely on a high degree of elasticity or compliance (Lentle et al ., 2013; Mijailovich et al ., 2007; Westerhof et al ., 2005). The elastic properties of these tissues are supported by a complex underlying fiber micro-architecture (Halloran et al ., 1995; Sokolis and Sassani, 2013; Wu et al ., 2011).…”

Section: Introductionmentioning

confidence: 99%

A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy

Koch

Tsamis

D’Amore

et al. 2014

Journal of Biomechanics

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The aorta possesses a micro-architecture that imparts and supports a high degree of compliance and mechanical strength. Alteration of the quantity and/or arrangement of the main load-bearing components of this micro-architecture the elastin and collagen fibers leads to mechanical, and hence functional, changes associated with aortic disease and aging. Therefore, in the future, the ability to rigorously characterize the wall fiber micro-architecture could provide insight into the complicated mechanisms of aortic wall remodeling in aging and disease. Elastin and collagen fibers can be observed using state-of-the-art multi-photon microscopy. Image-analysis algorithms have been effective at characterizing fibrous constructs using various microscopy modalities. The objective of this study was to develop a custom MATLAB-language automated image-based analysis tool to describe multiple parameters of elastin and collagen micro-architecture in human soft fibrous tissue samples using multi-photon microscopy images. Human aortic tissue samples were used to develop the code. The tool smooths, cleans and equalizes fiber intensities in the image before segmenting the fibers into a binary image. The binary image is cleaned and thinned to a fiber skeleton representation of the image. The developed software analyzes the fiber skeleton to obtain intersections, fiber orientation, concentration, porosity, diameter distribution, segment length and tortuosity. In the future, the developed custom image-based analysis tool can be used to describe the micro-architecture of aortic wall samples in a variety of conditions. While this work targeted the aorta, the software has the potential to describe the architecture of other fibrous materials, tube-like networks and connective tissues.

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Section: Introductionmentioning

confidence: 99%

A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy

Koch

Tsamis

D’Amore

et al. 2014

Journal of Biomechanics

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“…Smooth muscle tone specifically refers to the sustained state of contraction within a muscle and can be further separated into neurogenic and myogenic components 11 . Neurogenic tone has been well described in the human prostate, and is mediated by release of neurotransmitters from the autonomic nervous system, notably during ejaculation 12 .…”

Section: Introductionmentioning

confidence: 99%

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate

Lee

Chakrabarty²,

Wittmer

et al. 2017

Sci Rep

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Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) are highly prevalent in older men, having a profound impact on patient quality of life. Current therapeutics for BPH/LUTS target neurogenic smooth muscle tone, but response is unpredictable and many patients fail to respond. Spontaneous myogenic tone is another component of smooth muscle contractility that is uncharacterized in human prostate. To better understand and improve the predictability of patient response, we defined myogenic contractility using human prostate specimens and examined the effect of existing therapeutics. We show that myogenic activity is present in the human prostate with the frequency of contractions in transition zone (TZ) specimens from BPH diagnosed patients approximately 160% greater than matched controls. α1-adrenoreceptor antagonists (Tamsulosin) and PDE5 inhibitors (Sildenafil) both significantly reduced myogenic contractile parameters, including frequency, with notable interpatient variability. Tamsulosin was more effective in older patients (R2 = 0.36, p < 0.01) and men with larger prostate volumes (R2 = 0.41, p < 0.05), while Sildenafil was more effective in younger men (R2 = 0.45, p < 0.05). As myogenic tone is significantly increased in BPH, therapeutics targeting this mechanism used with reference to patient characteristics could improve clinical outcomes and better predict patient response.

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Gastrointestinal Motor Function

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Gastrointestinal Physiology

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Gastrointestinal tone; its genesis and contribution to the physical processes of digestion

Cited by 7 publications

References 111 publications

A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy

A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy

Age Related Differences in Responsiveness to Sildenafil and Tamsulosin are due to Myogenic Smooth Muscle Tone in the Human Prostate

Gastrointestinal Motor Function

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