Gastrointestinal and Liver Microcirculations: Roles in Inflammation and Immunity

Miura, Soichiro; Kubes, Paul; Granger, D. Neil

doi:10.1002/cphy.cp020414

Cited by 1 publication

(1 citation statement)

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“…These two vessels enter the liver and penetrate the liver parenchyma together and in close vicinity, and gradually branch until arterioles and venules. Upon reaching the periphery of the hexagonal liver lobules separately, the terminal portal venules enter the lobule in-between the cords of hepatocytes and continue with the sinusoids, a microvascular network which forms most of the capillary bed in the hepatic parenchyma [ 59 , 60 , 61 ]. The hepatic artery supplies oxygenated blood to the biliary tree (through the peribiliary plexus), portal tract interstitium and the vasa vasorum of the intrahepatic vessels.…”

Section: Characteristics Of the Liver Circulationmentioning

confidence: 99%

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

Németh

Pető

Magyar

et al. 2021

IJMS

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Hepatic ischemia-reperfusion injury (IRI) is a multifactorial phenomenon which has been associated with adverse clinical outcomes. IRI related tissue damage is characterized by various chronological events depending on the experimental model or clinical setting. Despite the fact that IRI research has been in the spotlight of scientific interest for over three decades with a significant and continuous increase in publication activity over the years and the large number of pharmacological and surgical therapeutic attempts introduced, not many of these strategies have made their way into everyday clinical practice. Furthermore, the pathomechanism of hepatic IRI has not been fully elucidated yet. In the complex process of the IRI, flow properties of blood are not neglectable. Hemorheological factors play an important role in determining tissue perfusion and orchestrating mechanical shear stress-dependent endothelial functions. Antioxidant and anti-inflammatory agents, ischemic conditioning protocols, dynamic organ preservation techniques may improve rheological properties of the post-reperfusion hepatic blood flow and target endothelial cells, exerting a potent protection against hepatic IRI. In this review paper we give a comprehensive overview of microcirculatory, rheological and molecular–pathophysiological aspects of hepatic circulation in the context of IRI and hepatoprotective approaches.

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Section: Characteristics Of the Liver Circulationmentioning

confidence: 99%