Gastroesophageal reflux disease after peroral endoscopic myotomy: Analysis of clinical, procedural and functional factors, associated with gastroesophageal reflux disease and esophagitis

Familiari, Pietro; Greco, S.; Gigante, G.; Calì, Anna; Boškoski, Ivo; Onder, Graziano; Perri, Vincenzo; Costamagna, Guido

doi:10.1111/den.12511

Cited by 107 publications

(71 citation statements)

References 49 publications

(130 reference statements)

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“…Familiari et al 26 identified that a lower IRP was associated with heartburn after POEM. Patient demographics, including age, body mass index, sigmoid oesophagus and previous therapies, did not significantly increase the risk of developing GORD.…”

Section: Discussionmentioning

confidence: 99%

Peroral endoscopic myotomy: a literature review and the first UK case series

Gulati¹,

Emmanuel²,

Inoue

et al. 2017

Clinical Medicine

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Peroral endoscopic myotomy (POEM) is an established treatment for primary achalasia. It has gained endorsement from the American Society for Gastrointestinal Endoscopy with increasing clinical acceptance since the fi rst procedure, performed in Japan in 2008. The fi rst successful POEM in the UK was performed in November 2013 at King's College Hospital and this article presents the fi rst UK case series. Prospective data were collected at 3 and 12-24 months for consecutive patients undergoing POEM. Post-POEM gastro-oesophageal refl ux health-related quality of life scale (GORD-HRQoL) score was recorded. Statistical comparisons were made using paired non-parametric testing. In an initial series of 33 consecutive prospectively followed patients (12 female; 49.5±13 years; median follow-up 9 (3-28) months; 58% having had previous intervention), a 91% success rate has been achieved at 3 months. To date, 16 patients have reached the 12-month time point, with 13 (81%) sustaining response. This case series compares well with international cohorts and demonstrates excellent long-term safety and favourable effi cacy.

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Section: Discussionmentioning

confidence: 99%

Peroral endoscopic myotomy: a literature review and the first UK case series

Gulati¹,

Emmanuel²,

Inoue

et al. 2017

Clinical Medicine

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“…Familiari et al reported that in 50.5% patients, abnormal acid exposure was found and clinically relevant GERD was evident in 29.1%. Esophagitis and symptoms resolved completely with proton pump inhibitor (30).…”

Section: Efficacy and Complicationmentioning

confidence: 95%

Peroral endoscopic myotomy (POEM) for treating esophageal motility disorders

Wong¹,

Law²

2017

Ann. Transl. Med.

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“…Hasta la fecha, solo cuatro series han presentado datos sustanciales sobre la evaluación de la ERGE en sus pacientes utilizando los tres métodos (evaluación sistemática de los síntomas, evaluación endoscópica y estudio ambulatorio de pH) 18,19 . Estos estudios hallaron que el 27-59% de los pacientes tenía signos endoscópicos de reflujo (principalmente esofagitis leve clase A o B de Los Ángeles), el 29-38% tenía anormalmente elevada la exposición al ácido en los estudios de pH y el 15-23% tenían los síntomas frecuentes de reflujo gastroesofágico 20,21 .…”

Section: El Poem Y La Enfermedad Por Reflujo Gastroesofágicounclassified

Miotomía esofágica endoscópica peroral para el tratamiento de la acalasia

Nieponice¹,

Nachman²

2022

NGL

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RESUMENLa práctica de la miotomía endoscópica peroral (POEM) para el tratamiento de la acalasia ha crecido vertiginosamente en los últimos cinco años y se está transformando en la primera opción terapéutica en varios centros especializados del mundo. La presente revisión detalla los orígenes de esta opción terapéutica, sus indicaciones, la técnica, un análisis de los resultados internacionales y una reseña de la experiencia de nuestro grupo. El trabajo analiza también el reflujo posmiotomía y su comparación con la miotomía laparoscópica de Heller, que es el gran punto de debate en estos tiempos. Los resultados actuales son prometedores, demuestran su seguridad y una recuperación más rápida del paciente, lo cual apoya la adopción del POEM como primera línea de tratamiento de la acalasia en un futuro. Se requiere sin embargo contar con un equipo multidisciplinario con amplia experiencia en endoscopia terapéutica, por lo cual es aconsejable limitar este procedimiento a centros de referencia y con alto volumen en esta patología. En conclusión, la seguridad y eficacia del POEM apoyan un cambio de paradigma respecto a la miotomía laparoscópica para el tratamiento de la acalasia.

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Gastroesophageal reflux disease after peroral endoscopic myotomy: Analysis of clinical, procedural and functional factors, associated with gastroesophageal reflux disease and esophagitis

Abstract: Preoperative, perioperative or postoperative factors minimally correlated with GERD after POEM. Clinically relevant GERD was identified in less than one-third of patients, but all patients were well controlled with medical therapy.

Cited by 107 publications

References 49 publications

Peroral endoscopic myotomy: a literature review and the first UK case series

Peroral endoscopic myotomy: a literature review and the first UK case series

Peroral endoscopic myotomy (POEM) for treating esophageal motility disorders

Miotomía esofágica endoscópica peroral para el tratamiento de la acalasia

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