Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-κB signaling activation in CD4+ T cells

Gao, Shu; Yang, Taowei; Wang, Chaoyuan; Su, Hexiu; Xiang, Ming

doi:10.1016/j.taap.2013.02.019

Cited by 60 publications

(24 citation statements)

References 42 publications

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“…Alkaloids are a group of naturally occurring chemical 140 [114][115][116][117][118][119] pathway and down-regulation of inhibitor of apoptosis proteins (18). Another study reports that matrine inhibits the invasive activities of human osteosarcoma cells through down-regulation of the ERK/NF-κB pathway in intro and in vivo (19).…”

Section: Alkaloidmentioning

confidence: 99%

“…Gastrodin, a natural product isolated from Gastrodia elata Blume, was demonstrated to repress the growth of H22 murine ascetic hepatoma cells by inhibiting the NF-κB signaling pathway (116). Stevioside, a diterpene glycoside found in the leaf of Stevia rebaudiana, was reported to induce ROS-mediated apoptosis of MCF-7 cells via the mitochondrial pathway (117).…”

Section: Glycosidementioning

confidence: 99%

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A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Xia

Chen

Zhang

et al. 2014

DD^|^T

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Section: Alkaloidmentioning

confidence: 99%

Section: Glycosidementioning

confidence: 99%

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Xia

Chen

Zhang

et al. 2014

DD^|^T

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“…13 NF-κB plays a key role in regulating the immune response to infection. Upon activation of either T or B-cell receptors, NF-κB is able to enter the nucleus to upregulate genes involved in T/B-cell maturation, proliferation and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Simvastatin Reduces Burn Injury-induced Splenic Apoptosis via Downregulation of the TNF-α/NF-κB Pathway

Zhao

Kaneki

et al. 2015

Annals of Surgery

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Objective Recent studies have suggested that epidermal burn injuries are associated with inflammation and immune dysfunction. Simvastatin has been shown to possess potent anti-inflammatory properties. Thus we hypothesized that simvastatin protects against burn-induced apoptosis in spleen via its anti-inflammatory activity. Methods Wild-type, tumor necrosis factor alpha knockout (TNF-αKO) and NF-κB KO mice were subjected to full-thickness burn injury or sham treatment. The mice then were treated with or without simvastatin and the spleen were harvested to measure the extent of apoptosis. Expression levels of TNF-αand NF-κB were also determined in spleen tissue and serum. Results Burn injury induced significant splenic apoptosis and systemic cytokine production. Simvastatin protected the spleen from apoptosis, reduced cytokine production in the serum and increased the survival rate. Simvastatin decreased burn-induced TNF-αand NF-κB expression in spleen and serum. TNF-αand NF-κB KO mice demonstrated lower levels of apoptosis in spleen in response to burn. Simvastatin did not further decrease burn-caused apoptosis and mortality in either strain of KO mice. Conclusions Simvastatin reduces burn-induced splenic apoptosis via down-regulation of the TNF-α/ NF-κB pathway.

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“…It is also considered to have health benefits, such as enhancing strength and virility as well as improving memory and blood circulation [2]. The active constituents, mainly identified from ethanol or methanol extracts, were reported to be 4-hydroxybenzyl analogues and 4-hydroxybenzylsubstituted metabolites [3]. As part of a program to assess the chemical and biological diversity of traditional Chinese medicines [4 -9], a detailed chemical study was conducted on the aqueous extract of G. elata rhizomes, together with biological assays, since their decoctions are practically used in a variety of formulations.…”

Section: Introductionmentioning

confidence: 99%

“…[13]. A further investigation of other minor components in the aqueous extract has resulted in the isolation and characterization of seven new 4-hydroxybenzylsubstituted glutathione derivatives (2)(3)(4)(5)(6)(7)(8),…”

Section: Introductionmentioning

confidence: 99%

4-Hydroxybenzyl-substituted glutathione derivatives fromGastrodia elata

Guo

Wang

Zhu

et al. 2015

Journal of Asian Natural Products Research

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Seven new 4-hydroxybenzyl-substituted glutathione derivatives (2-8), together with a known analogue (1), were isolated from the aqueous extract of Gastrodia elata Blume rhizomes. Their structures were determined by using spectroscopic and chemical methods. The absolute configurations of 1-8 were assigned by using Marfey's method, combined with comparing the NMR and CD spectroscopic data of sulfoxide moieties in 3-6 with those of S-(4-hydroxybenzyl)cysteine sulfoxide stereoisomers (9-12) synthesized as authentic samples. The configurations of 9-12 were confirmed by electronic CD calculations based on the quantum-mechanical time-dependent density functional theory. Furthermore, the structures of 1, 3, 5, 7, and 8 were verified by synthesis. Compound 3 was active against serum deprivation-induced PC12 cell damage and synthetic 9-14 exhibited activity against Fe(2+)-cysteine induced rat liver microsomal lipid peroxidation.

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Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-κB signaling activation in CD4+ T cells

Cited by 60 publications

References 42 publications

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

Simvastatin Reduces Burn Injury-induced Splenic Apoptosis via Downregulation of the TNF-α/NF-κB Pathway

4-Hydroxybenzyl-substituted glutathione derivatives fromGastrodia elata

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