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Cited by 100 publications
(58 citation statements)
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“…ERK1/2 is a member of the family of mitogen-activated protein kinases (MAPKs) and mediates different cellular events through signaling pathways [16,17] . Usually, the activation of ERK1/2 has a positive effect on neuronal cell survival [18,19] . However, persistent ERK1/2 activation is toxic to DA neurons [20] .…”
Section: Introductionmentioning
confidence: 99%
“…ERK1/2 is a member of the family of mitogen-activated protein kinases (MAPKs) and mediates different cellular events through signaling pathways [16,17] . Usually, the activation of ERK1/2 has a positive effect on neuronal cell survival [18,19] . However, persistent ERK1/2 activation is toxic to DA neurons [20] .…”
Section: Introductionmentioning
confidence: 99%
“…Over the past decade, few breakthroughs in the therapeutic intervention of PD have occurred, although advances in the understanding of oxidative stress leading to PD have significantly progressed (Wang et al, 2014). However, clinical drugs with few side effects are of high priority and urgently needed.…”
Section: Discussionmentioning
confidence: 99%
“…The study provided some evidences that PLA protected dopaminergic cells from MPTP neurotoxicity by ameliorating behavioral abnormalities, increasing levels of DA and its associated metabolites, and enhancing antioxidative defense by increasing GSH level and SOD activity, and decreasing MDA levels. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model which can cause human and animal PD symptoms is the most commonly used mouse model for studying PD (Wang et al, 2014). MPTP can selectively damage nigral compacta dopaminergic neurons (Sowell et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
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