Gastritis With Valproate Therapy

Protective Effect of L‐Arginine and Filgrastim Against Valproic Acid–Induced Histopathological Changes on the Gastric and Lingual Mucosa

“…According to previous animal studies, VPA can cause alterations such as reduced gastric motility and parietal cell atrophy. Overdosing may result in the formation of a pharmacobezoar (a solid drug mass that develops in the stomach), which is a dangerous complication and is resistant to treatment (Marks et al 1988;Alrazooqi et al 2025). This may help explain why PCN did not differ significantly among the groups.…”

Protective Effect of L‐Arginine and Filgrastim Against Valproic Acid–Induced Histopathological Changes on the Gastric and Lingual Mucosa

“…According to previous animal studies, VPA can cause alterations such as reduced gastric motility and parietal cell atrophy. Overdosing may result in the formation of a pharmacobezoar (a solid drug mass that develops in the stomach), which is a dangerous complication and is resistant to treatment (Marks et al 1988;Alrazooqi et al 2025). This may help explain why PCN did not differ significantly among the groups.…”

Primum non nocere: A case of valproate encephalopathy

“…Also, by inducing the competitive inhibition with succinic semial dehydrogenise and GABA transaminase and by stimulating GABA synthesizing enzymes such as glutamic acid dehydrogenise, it increases the concentration of GABA. [2,3] After oral intake, almost all of it is rapidly absorbed and, the sodium salt reaches top concentration in plasma, approximately after 1.5 hours. Uptaking after a meal, may delay absorption.…”

Improving tolerability of the ketogenic diet in patients with abnormal endoscopic findings

“…Corticosteroids are also frequently prescribed drugs, particularly in the treatment of infantile spasm and Lennox-Gastaut syndrome. Prolonged use of these drugs could cause GI disturbances in patients with intractable epilepsy, which may be a major cause of poor tolerance for the KD [15,16].…”

Protective Effect of L‐Arginine and Filgrastim Against Valproic Acid–Induced Histopathological Changes on the Gastric and Lingual Mucosa

“…According to previous animal studies, VPA can cause alterations such as reduced gastric motility and parietal cell atrophy. Overdosing may result in the formation of a pharmacobezoar (a solid drug mass that develops in the stomach), which is a dangerous complication and is resistant to treatment (Marks et al 1988;Alrazooqi et al 2025). This may help explain why PCN did not differ significantly among the groups.…”

Primum non nocere: A case of valproate encephalopathy

“…Also, by inducing the competitive inhibition with succinic semial dehydrogenise and GABA transaminase and by stimulating GABA synthesizing enzymes such as glutamic acid dehydrogenise, it increases the concentration of GABA. [2,3] After oral intake, almost all of it is rapidly absorbed and, the sodium salt reaches top concentration in plasma, approximately after 1.5 hours. Uptaking after a meal, may delay absorption.…”

Improving tolerability of the ketogenic diet in patients with abnormal endoscopic findings

“…Corticosteroids are also frequently prescribed drugs, particularly in the treatment of infantile spasm and Lennox-Gastaut syndrome. Prolonged use of these drugs could cause GI disturbances in patients with intractable epilepsy, which may be a major cause of poor tolerance for the KD [15,16].…”

Protective Effect of L‐Arginine and Filgrastim Against Valproic Acid–Induced Histopathological Changes on the Gastric and Lingual Mucosa

“…According to previous animal studies, VPA can cause alterations such as reduced gastric motility and parietal cell atrophy. Overdosing may result in the formation of a pharmacobezoar (a solid drug mass that develops in the stomach), which is a dangerous complication and is resistant to treatment (Marks et al 1988;Alrazooqi et al 2025). This may help explain why PCN did not differ significantly among the groups.…”

Primum non nocere: A case of valproate encephalopathy

“…Also, by inducing the competitive inhibition with succinic semial dehydrogenise and GABA transaminase and by stimulating GABA synthesizing enzymes such as glutamic acid dehydrogenise, it increases the concentration of GABA. [2,3] After oral intake, almost all of it is rapidly absorbed and, the sodium salt reaches top concentration in plasma, approximately after 1.5 hours. Uptaking after a meal, may delay absorption.…”

Improving tolerability of the ketogenic diet in patients with abnormal endoscopic findings

“…Corticosteroids are also frequently prescribed drugs, particularly in the treatment of infantile spasm and Lennox-Gastaut syndrome. Prolonged use of these drugs could cause GI disturbances in patients with intractable epilepsy, which may be a major cause of poor tolerance for the KD [15,16].…”