Gastrin has no promoting effect on chemically induced colonic tumors in wister rats

Effect of Cholecystokinin-B Gastrin Receptor Blockade on Chemically Induced Colon Carcinogenesis in Mice: Follow-Up at 52 Weeks

“…Though hypergastrinemia is not associated with increased colon cancer in both rats and humans [22, 23], the expression of gastrin and gastrin receptors in colorectal carcinoma cell lines suggests a potential role of gastrin in colon carcinogenesis [16, 17, 18]. An autocrine loop was tentatively proposed to explain the trophic role of gastrin in colorectal cancer [32, 33].…”

“…In addition, gastrin receptor antagonists showed antiproliferative effects on some human colon cancer lines [19, 20, 21]. However, life-long hypergastrinemia did not elicit colon cancer growth both in rats and humans [22, 23]and gastrin levels are normal in patients with colon carcinoma [24]. …”

Effect of Cholecystokinin-B Gastrin Receptor Blockade on Chemically Induced Colon Carcinogenesis in Mice: Follow-Up at 52 Weeks

“…Though hypergastrinemia is not associated with increased colon cancer in both rats and humans [22, 23], the expression of gastrin and gastrin receptors in colorectal carcinoma cell lines suggests a potential role of gastrin in colon carcinogenesis [16, 17, 18]. An autocrine loop was tentatively proposed to explain the trophic role of gastrin in colorectal cancer [32, 33].…”

“…In addition, gastrin receptor antagonists showed antiproliferative effects on some human colon cancer lines [19, 20, 21]. However, life-long hypergastrinemia did not elicit colon cancer growth both in rats and humans [22, 23]and gastrin levels are normal in patients with colon carcinoma [24]. …”

Enhancement by bombesin of colon carcinogenesis and metastasis induced by azoxymethane in wistar rats

“…Therefore, it is difficult to determine whether bombesin had an influence on colon carcinogenesis during the initiation phase or the progression phase. We previously found that prolonged administration of tetragastrin during the intra-rectal instillation of the carcinogenic solution resulted in a significant reduction in the incidence of colon tumors, but administration of tetragastrin after treatment with the carcinogen had little or no influence on the development of colon tumors, and concluded that tetragastrin had no promoting effect on colon carcinogenesis (Tatsuta et al, 1985). We also found that the administration of vasoactive intestinal peptide during treatment with the carcinogen significantly increased the incidence of colon tumors (Iishi et al, 1987).…”

Selective CCK‐A but not CCK‐B receptor antagonists inhibit HT‐29 cell proliferation: synergism with pharmacological levels of melatonin

“…Gastrin affects to a similar extend the growth of oxyntic glands, duodenum and colon mucosa [3]. Some reports have shown that gastrin and pentagastrin stimulate colonic neoplasm growth in cell culture [4, 5] and in vivo [6], but other workers were unable to confirm these data [7].…”

Effect of Cholecystokinin-B Gastrin Receptor Blockade on Chemically Induced Colon Carcinogenesis in Mice: Follow-Up at 52 Weeks

“…Though hypergastrinemia is not associated with increased colon cancer in both rats and humans [22, 23], the expression of gastrin and gastrin receptors in colorectal carcinoma cell lines suggests a potential role of gastrin in colon carcinogenesis [16, 17, 18]. An autocrine loop was tentatively proposed to explain the trophic role of gastrin in colorectal cancer [32, 33].…”

“…In addition, gastrin receptor antagonists showed antiproliferative effects on some human colon cancer lines [19, 20, 21]. However, life-long hypergastrinemia did not elicit colon cancer growth both in rats and humans [22, 23]and gastrin levels are normal in patients with colon carcinoma [24]. …”

Enhancement by bombesin of colon carcinogenesis and metastasis induced by azoxymethane in wistar rats

“…Therefore, it is difficult to determine whether bombesin had an influence on colon carcinogenesis during the initiation phase or the progression phase. We previously found that prolonged administration of tetragastrin during the intra-rectal instillation of the carcinogenic solution resulted in a significant reduction in the incidence of colon tumors, but administration of tetragastrin after treatment with the carcinogen had little or no influence on the development of colon tumors, and concluded that tetragastrin had no promoting effect on colon carcinogenesis (Tatsuta et al, 1985). We also found that the administration of vasoactive intestinal peptide during treatment with the carcinogen significantly increased the incidence of colon tumors (Iishi et al, 1987).…”

Selective CCK‐A but not CCK‐B receptor antagonists inhibit HT‐29 cell proliferation: synergism with pharmacological levels of melatonin

“…Gastrin affects to a similar extend the growth of oxyntic glands, duodenum and colon mucosa [3]. Some reports have shown that gastrin and pentagastrin stimulate colonic neoplasm growth in cell culture [4, 5] and in vivo [6], but other workers were unable to confirm these data [7].…”

Effect of Cholecystokinin-B Gastrin Receptor Blockade on Chemically Induced Colon Carcinogenesis in Mice: Follow-Up at 52 Weeks

“…Though hypergastrinemia is not associated with increased colon cancer in both rats and humans [22, 23], the expression of gastrin and gastrin receptors in colorectal carcinoma cell lines suggests a potential role of gastrin in colon carcinogenesis [16, 17, 18]. An autocrine loop was tentatively proposed to explain the trophic role of gastrin in colorectal cancer [32, 33].…”

“…In addition, gastrin receptor antagonists showed antiproliferative effects on some human colon cancer lines [19, 20, 21]. However, life-long hypergastrinemia did not elicit colon cancer growth both in rats and humans [22, 23]and gastrin levels are normal in patients with colon carcinoma [24]. …”

Enhancement by bombesin of colon carcinogenesis and metastasis induced by azoxymethane in wistar rats

“…Therefore, it is difficult to determine whether bombesin had an influence on colon carcinogenesis during the initiation phase or the progression phase. We previously found that prolonged administration of tetragastrin during the intra-rectal instillation of the carcinogenic solution resulted in a significant reduction in the incidence of colon tumors, but administration of tetragastrin after treatment with the carcinogen had little or no influence on the development of colon tumors, and concluded that tetragastrin had no promoting effect on colon carcinogenesis (Tatsuta et al, 1985). We also found that the administration of vasoactive intestinal peptide during treatment with the carcinogen significantly increased the incidence of colon tumors (Iishi et al, 1987).…”

Selective CCK‐A but not CCK‐B receptor antagonists inhibit HT‐29 cell proliferation: synergism with pharmacological levels of melatonin

“…Gastrin affects to a similar extend the growth of oxyntic glands, duodenum and colon mucosa [3]. Some reports have shown that gastrin and pentagastrin stimulate colonic neoplasm growth in cell culture [4, 5] and in vivo [6], but other workers were unable to confirm these data [7].…”