Gastric mucosa after partial gastrectomy.

Abstract

SUMMARY A partial gastrectomy of Billroth I or II type was performed in a series of 146 patients with peptic ulcer. Gastric biopsy was carried out two years later and the histology of the specimens compared with that of the body mucosa at the time of operation. In 138 patients without body atrophic gastritis (AG) before operation this condition was found in 74 (54 %) two years after (46 % of DU patients and 73 % of GU patients). Those with antral or pyloric canal ulcers were particularly liable to develop AG (81 %). Apart from site of ulcer various other factors possibly associated with the development of AG were examined: no positive correlations were found with the possible exception of anaemia. Gastric parietal cell antibodies were not found in any patient with AG tested. The cause of gastritis after partial gastrectomy and its possible relationship with gastric carcinoma are discussed.

Endoscopic Changes in the Gastric Stump Mucosa After Surgical Treatment for Ulcer Disease

“…In 58.2% of patients, resections of the stomach were done for recurrent ulcer or its complications, and in 41.8% for ulcer at the duodenal bulb or its complications. The obtained results agreed well with the results obtained in other studies (8)(9)(10).…”

“…Peptic ulcer disease is a defect in gastrointestinal mucosa as the result of inability of epithelial cells to resist the caustic action of HCl and pepsin present in the organ lumen. By their localization, ulcers can be divided into duodenal, distal gastric (antrum, prepyloric region), proximal gastric (angular portion, most of the corpus), and cardial ulcers (cardia and immediate subcardial portion) (1,2).…”

Etiology and Management of Chronic Gastritis

“…Pernicious anemia is well known to be accompanied by severe fundic gland atrophy with minimal inflammatory responses [34], and the majority of patients have parietal and intrinsic factor antibodies [35], Chronic gastritis commonly develops in the gastric remnant of patients after gastrectomy [36,37], and less frequently after vagotomy [38]. Bile reflux [39] has been thought to be an important factor, but the exact etiology is unknown.…”

Intragastric N-nitrosation is unlikely to be responsible for gastric carcinoma developing after operations for duodenal ulcer.

“… 5. Hourly mean values oftotal N-nitrosocompounds ,MIl in controls (top left), after proximal gastric vagotomy (bottom left), truncal vagotomy and pyloroplasty (top right) and truncal vagotomy and antrectomy (bottom right)…”