Gastric motor dysfunction coincides with the onset of obesity in rats fed with high‐fat diet

Kaya, Sabriye; Sinen, Osman; Bülbül, Mehmet

doi:10.1111/1440-1681.13448

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…The incidence rate of obesity keeps increasing for many years due to the improvement of living standards, excessive calorie intake and lack of physical exercise ( 28 ). High-fat diet is the direct cause of obesity ( 6 ). Extensive researches showed ANGPTL4 was an important regulator of TG metabolism by inhibiting LPL and pancreatic lipase ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidences indicate that gut microbiota directly participates in obesity and many other metabolic diseases ( 4 , 5 ). A recent study have shown that obesity could be induced by the high-fat diet (HFD) ( 6 ). Meanwhile, the dysregulation in the composition and metabolic functions of gut microbiota would promote the development of obesity ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet

et al. 2021

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Increasing studies have shown that obesity is the primary cause of cardiovascular diseases, non-alcoholic fatty liver diseases, type 2 diabetes, and a variety of cancers. The dysfunction of gut microbiota was proved to result in obesity. Recent research indicated ANGPTL4 was a key regulator in lipid metabolism and a circulating medium for gut microbiota and fat deposition. The present study was conducted to investigate the alteration of gut microbiota and ANGPTL4 expression in the gastrointestinal tract of mice treated by the high-fat diet. Ten C57BL/6J mice were randomly allocated to two groups and fed with a high-fat diet (HFD) containing 60% fat or a normal-fat diet (Control) containing 10% fat. The segments of ileum and colon were collected for the determination of ANGPTL4 expression by RT-qPCR and immunohistochemical analysis while the ileal and colonic contents were collected for 16S rRNA gene sequencing. The results showed HFD significantly increased mice body weight, epididymal fat weight, perirenal fat weight, liver weight, and the lipid content in the liver (P < 0.05). The relative expression of ANGPTL4 and the ANGPTL4-positive cells in the ileum and colon of mice was significantly increased by HFD treatment. Furthermore, 16S rRNA gene sequencing of the ileal and colonic microbiota suggested that HFD treatment changed the composition of the gut microbiota. The ratio of Firmicutes to Bacteroidetes and the abundance of Allobaculum was significantly higher in the HFD group than in the Control group while the abundance of Adlercreutzia, Bifidobacterium, Prevotellaceae UCG-001, and Ruminococcus was significantly decreased. Interestingly, the abundance of Allobaculum was positively correlated with the expression of ANGPTL4. These findings provide a theoretical foundation for the development of strategies to control the obesity and related diseases by the regulation of ANGPTL4 and gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet

et al. 2021

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“…Furthermore, studies in rats fed a high‐fat diet demonstrated that the increased visceral fat mass was linked with the development of a delayed gastric emptying, with attenuated bethanecol and sodium nitroprusside‐induced motor responses in antral and fundic isolated tissues. According to this model, gastric dysmotility linked with the over‐storage of visceral fat could depend on secondary alterations in the non‐adrenergic non‐cholinergic inhibitory neurotransmission 58 …”

Section: Discussionmentioning

confidence: 99%

“…According to this model, gastric dysmotility linked with the over-storage of visceral fat could depend on secondary alterations in the non-adrenergic non-cholinergic inhibitory neurotransmission. 58 Finally, an improvement of postprandial gastric emptying might also depend on varied levels of specific enterohormones affecting gastric motility. Glucagon-like peptide 1 (GLP-1) is secreted from the enterocytes following the luminal bile acid activation of the membrane receptor G protein-coupled receptor (GPBAR-1).…”

Section: Gastrointestinal Motility and Symptomsmentioning

confidence: 99%

Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility

Abdallah,

Khalil,

Farella

et al. 2023

Eur J Clin Investigation

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BackgroundRamadan is a model of intermittent fasting linked with possible beneficial effects. Scarce information, however, is available about the combined effects of Ramadan intermittent fasting (RIF) on anthropometric and metabolic indices, gastrointestinal symptoms, and motility.MethodsIn 21 healthy Muslims, we assessed the impact of RIF on caloric intake, physical activity, gastrointestinal symptoms and motility (gastric/gallbladder emptying by ultrasonography, orocaecal transit time by lactulose breath test), anthropometric indices, subcutaneous and visceral fat thickness (ultrasonography), glucose and lipid homeostasis.ResultsMean caloric intake decreased from a median of 2069 kcal (range 1677–2641) before Ramadan to 1798 kcal (1289–3126) during Ramadan and increased again to 2000 kcal (1309–3485) after Ramadan. Although physical activity remained stable before, during, and after RIF, body weight, body mass index and waist circumference decreased in all subjects and in both genders, together with a significant decrease in subcutaneous and visceral fat thickness and insulin resistance. The postprandial gastric emptying speed was significantly faster after than before RIF. Fasting gallbladder volume was about 6% smaller after, than before Ramadan, with a stronger and faster postprandial gallbladder contraction. After RIF, lactulose breath test documented increased microbiota carbohydrate fermentation (postprandial H2 peak), and faster orocaecal transit time. RIF also significantly improved gastric fullness, epigastric pain and heartburn.ConclusionsRIF generates, in healthy subjects, multiple systemic beneficial effects in terms of fat burden, metabolic profile, gastrointestinal motility and symptoms. Further comprehensive studies should assess the potential beneficial effects of RIF in diseased people.

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“…In recent years, several reports have revealed that a correlation exists between NAFPD and MetS and suggest that it must be part of the definition of MetS[ 77 - 79 ]. Altered metabolism of fatty acids, induced by abdominal obesity, is a risk factor for cardiovascular disease and gastrointestinal disorders, including of the pancreas[ 80 , 81 ]. Whether the association of NAFPD and MetS is directly causal, or is a result of obesity, remains unclear and awaits further investigation.…”

Section: Clinical Consequences Of Nafpdmentioning

confidence: 99%

Nonalcoholic fatty pancreas disease: An emerging clinical challenge

Zhang¹,

Wang²,

Li³

et al. 2021

WJCC

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Nonalcoholic fatty pancreas disease (NAFPD) is an emerging disease that has gained an increasing amount of attention in recent years. It describes fat accumulation in the pancreas with insignificant alcohol consumption, but the pathogenesis is largely unknown. A wide range of terms have been used to describe the phenomenon of pancreatic fat accumulation, but NAFPD remains an under-recognized and non-independent disorder. Obesity, age, sex, race, and unhealthy lifestyle are established independent risk factors for NAFPD, which is strongly associated with metabolic syndrome, type 2 diabetes, pancreatitis, pancreatic fistula, pancreatic cancer, and nonalcoholic fatty liver disease. At present, imaging techniques are common diagnostic aids, but uniform criteria and consensus are lacking. Therapeutically, healthy diet, weight loss, and exercise are the mainstays to reduce pancreatic fat accumulation. It can be seen that there is a limited understanding of NAFPD at this stage and further exploration is needed. Previous studies have revealed that NAFPD may directly affect diagnosis and clinical decision-making. Therefore, exploring the pathophysiological mechanism and clinical associations of NAFPD is a major challenge for researchers and clinicians.

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Gastric motor dysfunction coincides with the onset of obesity in rats fed with high‐fat diet

Cited by 4 publications

References 37 publications

Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet

Allobaculum Involves in the Modulation of Intestinal ANGPTLT4 Expression in Mice Treated by High-Fat Diet

Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility

Nonalcoholic fatty pancreas disease: An emerging clinical challenge

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