Gastric metastasis as the first manifestation of an invasive lobular carcinoma of the breast

Dória, Maíra Teixeira; Maesaka, Jonathan Yugo; Martins-Filho, Sebastião N.; Silveira, T.; Boufelli, Gabriela; Siqueira, Sheila Aparecida Coelho; Baracat, Edmund Chada; Filassi, José Roberto

doi:10.4322/acr.2015.018

Cited by 13 publications

(21 citation statements)

References 23 publications

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“…Some authors recommended surgical treatment in the case of solitary gastric metastasis, followed by chemotherapy and hormonal therapy, surgical resection in these cases bringing survival benefit (67,68) or when gastric metastasis was the first symptom of lobular breast carcinoma with a long period of latency before presentation of the primary breast carcinoma (69,70).…”

Section: Therapeutic Approachmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

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Section: Therapeutic Approachmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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“…The most common histological pattern found in gastric metastasis is adenocarcinoma with signet ring cells; this pattern can be confused with primary gastric cancer, as said in the reviews; indeed in three case reports [37][38][39] preoperative findings showed this pattern on gastric biopsies and surgical treatment was performed.…”

Section: Part 3 Comparison Between Reviews and Case Reportsmentioning

confidence: 88%

“…The preferred treatment is systemic therapy, as chemotherapy, endocrine therapy or a combination of both of them; 41 of the patients were subjected to chemotherapy with or without hormonal therapy. Combination of surgery and chemotherapy was used in 10 patients [23,28,29,35,[37][38][39]41,43,45] ; two of them [28,29] were submitted to neoadjuvant chemotherapy followed by surgery in the belief of a primary gastric cancer. Surgical treatment alone was chosen in 7 [26,27,42] patients, with three [27,42] of them in an emergency setting for bleeding and perforation.…”

Section: Therapymentioning

confidence: 99%

Breast cancer metastasis to the stomach

D’Angelo¹,

Rampini²,

Cardella³

et al. 2019

JCMT

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Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer. Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from 2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms, endoscopic findings, therapy, histology, and immunohistochemistry. Results: The incidence of stomach as site of metastasis of breast cancer ranges from 5% to 18%. Reviews and case reports reached similar conclusions about several of the aforementioned aspects: invasive lobular breast cancer (ILC) is mainly responsible for gastric metastases; disease free survival can vary greatly ranging from 0.5 months to 30 years; gastric metastases usually present with non-specific symptoms, even though five patients in case reports were asymptomatic; linitis plastica is the most common endoscopic finding; immunohistochemistry is essential for differentiating primary gastric cancer from metastasis; the preferred treatment is systemic therapy, but surgery is still an option in case of emergency; median overall survival of patients with gastric metastasis from breast cancer is 24 months. Conclusion: Breast metastasis to the stomach should be considered in any patient suspecting gastric neoplasm previously treated for breast carcinoma, especially if the treated carcinoma was ILC.

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“…La incidencia de metástasis gastrointestinales en autopsias varía entre un 6 y un 35%. La afectación del colon se ha documentado hasta en un 12% en autopsias 10 . El estómago es el órgano más afectado.…”

Section: Discussionunclassified

Inusual metástasis a colon de primario de mama

Salazar-Campos¹,

Lara-Hernández²,

Nieto-Coronel³

et al. 2022

GAMO

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El cáncer de mama es la primera causa de muerte en mujeres y la segunda causa mundial de muerte. Los sitios comunes de metástasis son hígado, pulmón, cerebro y hueso. Las metástasis gastrointestinales son poco frecuentes, siendo el estómago el sitio más afectado, seguido del duodeno y el colon. El carcinoma ductal presenta metástasis con más frecuencia a pulmón, hueso e hígado, mientras que el lobulillar involucra mayormente el tracto gastrointestinal, superficie peritoneal y retroperitoneo. Se presenta el caso de una paciente de 45 años con cáncer de mama de rápida instalación y progresión, tipo inflamatorio, lobulillar, HER-2 sobreexpresado, con tumoración a nivel de colón transverso con biopsia que corroboró metástasis a colon de primario de mama. Se realizó una búsqueda sistemática en Google Schoolar y Pubmed/MEDLINE y se hallaron 40 casos; de acuerdo con lo encontrado, las metástasis a colon por cáncer de mama representan el tercer lugar de afectación del tracto gastrointestinal y el tiempo transcurrido desde el diagnóstico del cáncer primario de mama hasta el diagnóstico de la metástasis a colon en promedio es de 6.9 años. El 50% corresponden a la histología lobulillar y el 35%, ductal. La mayoría expresa receptores de estrógenos (RE) y citoqueratinas (CK), principalmente CK7. Se debe realizar un adecuado abordaje en las pacientes que presenten sintomatología gastrointestinal o tumor intestinal, ya que el tratamiento es completamente diferente si es metastásico de mama o si se trata de un segundo tumor primario.

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Gastric metastasis as the first manifestation of an invasive lobular carcinoma of the breast

Cited by 13 publications

References 23 publications

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Breast cancer metastasis to the stomach

Inusual metástasis a colon de primario de mama

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