2011
DOI: 10.1152/ajpregu.00139.2011
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Gastric bypass reduces fat intake and preference

Abstract: Roux-en-Y gastric bypass is the most effective therapy for morbid obesity. This study investigated how gastric bypass affects intake of and preference for high-fat food in an experimental (rat) study and within a trial setting (human). Proportion of dietary fat in gastric bypass patients was significantly lower 6 yr after surgery compared with patients after vertical-banded gastroplasty (P = 0.046). Gastric bypass reduced total fat and caloric intake (P < 0.001) and increased standard low-fat chow consumption … Show more

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Cited by 210 publications
(214 citation statements)
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“…B: total caloric intake (means Ϯ SE) from presurgical baseline and daily during the 8-day postsurgical choice testing between the surgical groups. taining 60% fat such as Research Diets D12492; 14, 22, 26, 27, 37), a pure fat solid or fluid (such as corn oil or Intralipid; 14,16,17,26,36), or a full-nutrition sweet and fatty beverage (Ensure; 5, 16, 17, 26, 37) after surgery. These animals also choose to consume proportionally greater amounts of normal chow or other low-fat/low-sugar choices (e.g., water, V8 vegetable drink) than sham-operated rats.…”
Section: Discussionmentioning
confidence: 99%
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“…B: total caloric intake (means Ϯ SE) from presurgical baseline and daily during the 8-day postsurgical choice testing between the surgical groups. taining 60% fat such as Research Diets D12492; 14, 22, 26, 27, 37), a pure fat solid or fluid (such as corn oil or Intralipid; 14,16,17,26,36), or a full-nutrition sweet and fatty beverage (Ensure; 5, 16, 17, 26, 37) after surgery. These animals also choose to consume proportionally greater amounts of normal chow or other low-fat/low-sugar choices (e.g., water, V8 vegetable drink) than sham-operated rats.…”
Section: Discussionmentioning
confidence: 99%
“…While self-report measures in humans are vulnerable to inaccuracies (e.g., 9, 15, 23, 24, 33; also see 19), these results are mirrored in rat models of RYGB. After RYGB, rats lose body weight, consume fewer overall calories, and show blunted preferences for high-fat laboratory diets, as well as for sucrose solutions, the soybean oil emulsion Intralipid, and dietary supplements like Ensure that are high in fat and sugar (e.g., 3,5,14,16,22,26,27,36,37).Although these data from rodent models of RYGB are compelling, the nutritive stimuli studied are not always representative of "real-world" choices from which patients will select their new diet. We addressed this in the current report by presenting rats before and after either RYGB or a sham operation with a "cafeteria" or "supermarket" diet, which consists of ad libitum access to many different palatable items (For reviews see 25, 34).…”
mentioning
confidence: 99%
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“…In obese subjects, dietary restriction reduced the spontaneous consumption of foods high in fat (48), while patients with a gastric bypass find fatty meals less pleasant (136). The effectiveness of bariatric surgery is partly due to a selective reduction in the reward value of palatable foods both in humans and rodents (107,135,191). To date, effect of the reduction of fat mass on oral fat detection remains poorly documented.…”
Section: Effect Of Fat Massmentioning
confidence: 99%