GAS5‑mediated regulation of cell signaling (Review)

Abstract

in recent years, an increasing number of long non-coding rnas (lncrnas) have been discovered using microarrays and nucleic acid sequencing technology. lncrnas exert crucial biological functions by regulating signaling pathways. In particular, the lncRNA growth arrest-specific transcript 5 (GaS5) has been documented to serve a crucial role in numerous signaling pathways. This article discusses the latest developments in the association between GaS5 and microrna (mirna), p53, mTor, glucocorticoid response element (Gre) and aKT in order to investigate the roles served by GaS5. mirnas can activate related signaling pathways and GaS5 can combine with mirna to regulate related signaling pathways. GaS5 may regulate p53 expression via derivation of snorna, but the underlying mechanism requires further investigation. GaS5 overxpresion reduces the expression level of mTor, which is induced by inhibiting mir-106a-5p expression. GaS5 is a sponge of Gr, and serves a role in controlling and maintaining glucocorticoid sensitivity and drug resistance via competitive combination with Gr. GaS5 can interact with mirnas, such as mir-21 and mir-532-5p, to regulate the expression of aKT signaling pathway, affecting cell survival and apoptosis. collectively, the data indicate that GaS5 serves a key role in the mirna, p53, mTor, Gre, and aKT signaling pathways. GaS5 regulates complex intracellular signaling pathways primarily through three modes of action, all of which are interrelated: Signal, decoy and guide. in the present article, latest developments in the association between GaS5 and a number of cellular signaling pathways are discussed to examine the tumor suppressive role of GaS5. Contents 1. introduction 2. Four modes of action by which GaS5 regulates signaling pathways 3. regulation of gene expression by GaS5 4. GaS5 and the p53 network 5. GaS5 and mTor 6. GaS5 and microrna (mir or mirna) 7. GaS5 and glucocorticoid response element (Gre) 8. GaS5 and aKT 9. conclusion GAS5-mediated regulation of cell signaling (Review)

Non-Coding RNAs in the Transcriptional Network That Differentiates Skeletal Muscles of Sedentary from Long-Term Endurance- and Resistance-Trained Elderly

“…As an example of the complex interactions involving messenger, long-non-coding and micro RNAs, Figure 6 shows a hypothetical view of the transcriptional network regulating the transactivating activity of the androgen hormone receptor, involving lnc-RNA GAS5 , miR-106a-5p, miR-486-3p, miR-4429, and several protein-coding genes, based on expression data presented here and in [ 7 ] and on data found in [ 46 , 47 , 48 , 49 ]. As discussed by Wyce et al [ 47 ], the androgen receptor has a critical role in muscle function, a circumstance which makes this example a particularly relevant one.…”

The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

“…The first was that GAS5 expression This includes the formation of a GAS5/protein complex regulating gene expression on the transcription level and finally again (c) indirectly through the formation of a GAS5/protein complex, which acts as a post-transcriptional regulatory mechanism. (The diagram was adopted from [20]. Exemplary molecules presented include the crystal structure of the DNA-free Glucocorticoid Receptor DNA Binding Domain with reference no.…”

Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells

“…GAS5 was identified in network 3 with DLEU1, SOX2-OT, CYTOR (LINC00152), and TUB1 ( Figure 3 ) and was depicted as interacting with P53. Although a role for GAS5 in regulating P53 in BC is unknown, this association has been detected in other cancers, e.g., neuroblastoma (reviewed in [ 130 ]). The reduction of GAS5 abundance by miR-29a-3p and miR-29b-1-3p in LCC9 fits with their ‘anti-tumorigenic’ activity in BC (reviewed in [ 30 ]).…”