Gas-Liquid Chromathermography

Nerheim, A. G.

doi:10.1021/ac60159a039

Cited by 19 publications

(4 citation statements)

References 3 publications

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“…Tudge reviewed this and several other Russian papers related to chromathermography and contributed to this technique's theory [45]. In the USA, Nerheim published a paper on this method [46]. This work generated a heated zone by a glass sleeve wrapped with heating tape that was moved along a short linear glass GC column.…”

Section: Graphical Representation Of the Different Modes Of Chromatog...mentioning

confidence: 99%

Perspective Chapter: Negative Thermal Gradient Gas Chromatography

Rosenberg¹,

Klampfl²,

Müller³

2023

Novel Aspects of Gas Chromatography and Chemometrics

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Gas chromatography is typically operated in isothermal mode for optimum separation of a mixture of compounds with a narrow boiling point range, or in temperature-programmed mode, which strives to achieve a compromise between separation efficiency and time. Temperature gradients also keep the peak widths nearly constant over a wide range of retention times, enhancing the detectability of the later eluting peaks. In this chapter, the use of negative thermal gradients for gas chromatography (NTGGC) – for the sake of simplicity, subsequently only denoted as thermal gradient-gas chromatography, TGGC – shall be discussed. (N)TGGC is achieved by producing a stationary temperature gradient along the relatively short GC column in a proprietary experimental setup that allows cooling on one end of the column and heating on the other. The sample is injected into the hot end of the GC column, and analytes move towards the colder end of the column. Along their passage through the column, they are focused by the increasingly lower temperature of the stationary phase. This leads to a focusing of the peaks as they reach the cold column end. With appropriate temperature programming, very fast (sub-minute) chromatography with excellent resolution can be achieved on short GC columns. The present contribution will both discuss the theory behind this unusual, but highly performant mode of gas chromatographic separation, and also the hardware aspects of this technique. Relevant examples will be presented which highlight both the speed and the separation power by which (N)TGGC excels in comparison with regular temperature-programmed GC.

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Section: Graphical Representation Of the Different Modes Of Chromatog...mentioning

confidence: 99%

Perspective Chapter: Negative Thermal Gradient Gas Chromatography

Rosenberg¹,

Klampfl²,

Müller³

2023

Novel Aspects of Gas Chromatography and Chemometrics

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show abstract

“…The method claims particular effectiveness in trace enrichment. The whole separation, however, is confined to the length of the applied gradient, which therefore should be reasonably long enough with longitudinal temperature gradients of 2 °C/cm (2) and of an adjustable 1.0-8.5 °C/cm (3).) The ultimate separation efficiency, at the same time, obviously decreases with the steepness of the applied thermal gradient, and it is always less than that of the isotherm method (3).…”

Section: Literature Citedmentioning

confidence: 99%

“…Figure 2b sketches the result after the first ZGC scan (position of the heat pulse is as indicated): A sufficiently volatilized component (1) travels along with (and within) the heat pulse and is eluted completely. An insufficiently vola- tilized component (2) slowly phases out, and thus considerably spreads throughout the column, with only traces of it eluting.…”

Section: Zgc_tlor Isotherm Gcmentioning

confidence: 99%

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Zone gas chromatography

Fuggerth¹

1989

Anal. Chem.

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A different operational mode for addressing the general elution problem in rapid analysis gas chromatography

Rubey

1991

J. High Resol. Chromatogr.

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SummaryThe task of chromatographically separating a complex mixture containing constituents with a wide range of molecular weight has been referred to in the past as the "general elution problem". A different operational mode for conducting gas chromatography, thermal gradient programmed gas chromatography, presently in the developmental stage, has been investigated and is proposed as a means whereby such separations might be accomplished rapidly.The inherent versatility of the technique for conducting rapid analyses (50 to 300 s duration) of complicated samples containing constituents with a wide range of volatility is considered in terms of the possibility of achieving the maximum amount of analytical information per unit time.

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Gas-Liquid Chromathermography

Cited by 19 publications

References 3 publications

Perspective Chapter: Negative Thermal Gradient Gas Chromatography

Perspective Chapter: Negative Thermal Gradient Gas Chromatography

Zone gas chromatography

A different operational mode for addressing the general elution problem in rapid analysis gas chromatography

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