GAPSS: the Global Anti-Phospholipid Syndrome Score

Sciascia, Savino; Sanna, Giovanni; Murru, Veronica; Roccatello, Dario; Khamashta, Munther A.; Bertolaccini, Maria Laura

doi:10.1093/rheumatology/kes388

Cited by 257 publications

(227 citation statements)

References 22 publications

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“…The APS-Score [18,19] and GAPPSS [20] showed that multiple positivity for aPL will increase the thrombotic risk. Testing aPS/PT would be useful for the prediction of the thrombotic risk in patients with APS.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies

et al. 2014

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Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) were strongly correlated with the presence of lupus anticoagulant showing a high specificity for the diagnosis of antiphospholipid syndrome. However, the main criticism for the clinical applicability of aPS/PT testing is the lack of reproducibility of the results among laboratories. In this study, we measured IgG and IgM aPS/PT using our original in-house enzyme-linked immunosorbent assays (ELISA) and commercial ELISA kits to assess the assay performance and to evaluate the accuracy of aPS/PT results.The study included 111 plasma samples collected from patients and stored at our laboratory for aPS/PT assessment. Sixty-one samples were tested for IgG aPS/PT using two assays: 1) aPS/PT ELISA in-house ELISA and 2) QUANTA Lite In conclusion, IgG and IgM detection by ELISA is accurate. The performance of aPS/PT is reliable and concordant results can be obtained using different ELISA methods.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies

et al. 2014

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“…In our previous study we have reported that aPS/PT of IgG and IgM isotype are strongly associated with adverse pregnancy outcome, irrespective of other antiphospholipid antibodies [22], and that their detection is particularly important for evaluation of obstetric APS. However in the present study, we show that IgA aPS/PT (differently from IgG and IgM) were not found more prevalently in women with pregnancy complications.…”

Section: Discussionmentioning

confidence: 96%

“…In the last decade, antibodies against prothrombin, specifically aPS/PT were recognized to be importantly associated with clinical manifestations of APS [20][21][22][23]28]. In our previous study we have reported that aPS/PT of IgG and IgM isotype are strongly associated with adverse pregnancy outcome, irrespective of other antiphospholipid antibodies [22], and that their detection is particularly important for evaluation of obstetric APS.…”

Section: Discussionmentioning

confidence: 99%

“…Although antiprothrombin antibodies have not yet been included in the classification criteria of APS, they are emerging as an increasingly important supportive marker [1,[19][20][21]. We have previously reported of IgG and/or IgM antibodies against complex phosphatidylserine/prothrombin (aPS/PT) exhibiting the highest percentage of LA activity, as compared to aCL or anti-β2GPI [19] and their strong association to thrombosis and adverse pregnancy outcome, irrespective of other antiphospholipid antibodies [20,22]. The latest systematic review concluded that routine measurement of aPS/PT antibodies of IgG and/or IgM isotype in serum or plasma might be useful in establishing the thrombotic risk of patients with previous thrombosis and/or (SLE) [21].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence and Clinical Significance of Iga Anti-Phosphatidylserine/ Prothrombin Antibodies in Systemic Autoimmune Diseases

Å1⁄2igon¹,

AmbroÅ3⁄4iÄ²,

Mali³

et al. 2017

Immunome Res

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Objective: Studies on antiphospholipid antibodies have mainly focused on the IgG and IgM isotypes, with only a few investigating the pathogenic significance of IgA antiphospholipid antibodies. Positive IgA anticardiolipin (aCL) and IgA anti-β2 glycoprotein I (anti-β2GPI) were reported to be predominantly associated with other antiphospholipid antibodies, making it difficult to understand the role of IgA alone. Recently, antibodies against phosphatidylserine/ prothrombin (aPS/PT) IgG and IgM have been indicated as a potential marker for antiphospholipid syndrome (APS). Our previous study reported that IgG and IgM aPS/PT showed highest association with lupus anticoagulant (LA) activity of all tested antiphospholipid antibodies, while no studies to date have investigated possible clinical benefits of IgA aPS/PT. In this study, we determined the prevalence of IgA aPS/PT in patients with systemic autoimmune diseases and evaluated their clinical association to thrombosis and obstetric complications.Methods: 254 patients with systemic autoimmune diseases were screened for LA, aCL, anti-β2GPI and aPS/PT (for IgG, IgM, IgA isotypes).Results: An overall prevalence of 63/254 (25%) was found for IgA aPS/PT in our cohort of patients. IgA aPS/PT were statistically significantly associated to LA activity and to both arterial and venous thrombosis, however no association was found to obstetric complications. Median levels of IgA aPS/PT were significantly higher in APS patients than in the non-APS patient control group comprising systemic lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome patients. Conclusion:Although IgA aPS/PT were predominantly associated with other antiphospholipid antibodies this study first confirmed their presence in APS patient samples and also showed a clear association of IgA aPS/PT to thrombosis and LA activity.

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“…The parameters and scores included in GAPSS are hyperlipidemia (score 3), arterial hypertension (score 1), IgG/IgM aCL (score 5), IgG/IgM ab 2 GPI (score 4), IgG/IgM antiphosphatidyl serine (aPS)/anti prothrombin (score 3), and LAC (score 4). A GAPSS value of C10 or C11 was reported to have the best diagnostic accuracy for thrombosis or pregnancy loss [34][35][36].…”

Section: Risk Of Thrombosis Assessment-global Antiphospholipid Score mentioning

confidence: 99%

The Laboratory Diagnosis of the Antiphospholipid Syndrome

Ahluwalia

Sreedharanunni

2016

Indian J Hematol Blood Transfus

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The Antiphospholipid Syndrome (APS) is classified based on the presence of both clinical and laboratory criteria. Both sets of criteria are subject to much review and intense research as it is becoming increasingly clear that no single test is specific for defining this autoimmune disorder. A number of leading international bodies have released guidelines in an attempt to improve the laboratory testing and reporting. The current review is an appraisal of some of the literature pertaining to the laboratory testing.

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GAPSS: the Global Anti-Phospholipid Syndrome Score

Abstract: These data propose a substantial improvement in risk prediction of thrombosis or PL in SLE based on assessment of the GAPSS, a quantitative scoring system.

Cited by 257 publications

References 22 publications

Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies

Comparative analysis of different enzyme immunoassays for assessment of phosphatidylserine-dependent antiprothrombin antibodies

The Prevalence and Clinical Significance of Iga Anti-Phosphatidylserine/ Prothrombin Antibodies in Systemic Autoimmune Diseases

The Laboratory Diagnosis of the Antiphospholipid Syndrome

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