Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

Kang, Lihua; Zhang, Guowei; Zhang, Junfang; Qin, Bai; Guan, Huaijin

doi:10.1016/s1875-5364(20)60037-1

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Epigallocatechin gallate prevented UVB-induced oxidative stress and inhibited apoptosis-related death of LECs [ 24 ]. Ganoderic acid A protected LECs against UVB irradiation and delayed lens opacity [ 25 ]. Paeoniflorin inhibited epithelial–mesenchymal transformation and oxidative damage to LECs and exhibited benefits in preventing diabetic cataracts [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway

Guo¹,

Dong²

2022

Bioengineered

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Cataract is a global ophthalmic disease that blinds the eye, and oxidative stress is one of its primary causes. Apoptosis of lens epithelial cells (LECs) is considered the major cytological basis of many cataracts except congenital cataracts. The purpose of this study was to investigate whether diosmetin could reduce oxidative stress-induced damage to LECs, and explore its regulatory pathway. Lens epithelial cell line SRA01/04 was used as the object of study. Using ultraviolet B (UVB) and hydrogen peroxide (H 2 O 2 ) as sources of oxidative stress, the protective effects of diosmetin at different concentrations on cells were investigated, including inhibition of proliferation, apoptosis, and oxidative stress. Molecular docking was then used to predict the target proteins and validation was performed at the cellular and protein levels. The oxidative stress of SRA01/04 was induced by UVB and H 2 O 2 , and inhibition of proliferation and apoptosis were observed. Here, diosmetin has a dose-dependent cell-protecting effect. This effect is achieved by targeting the MEK2 protein and inhibiting the MAPK signaling. In conclusion, diosmetin reduces H 2 O 2 - and UVB-induced inhibition of SRA01/04 proliferation and apoptosis by reducing oxidative stress-induced activation of the MAPK pathway.

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Section: Discussionmentioning

confidence: 99%

Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway

Guo¹,

Dong²

2022

Bioengineered

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show abstract

“…Cataracts are a common lens disease worldwide and are one of the main causes of blindness. Ultraviolet B (UVB) irradiation is considered an important factor leading to the formation of cataracts by inducing the apoptosis of human lens epithelial cells (HLECs) ( 1 , 2 ). The photobiological effects of UVB may lead to reactive oxygen species (ROS) generation ( 3 ), DNA damage ( 4 ) and apoptosis ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…UVB can lead to the apoptosis of HLECs through the caspase-dependent pathway ( 1 ), whereas EGCG may reduce oxidant damage and thus protect HLECs from apoptosis ( 19 – 21 ). Heo et al ( 22 ) first reported in 2008 that EGCG increased the cell viability and cell count after UVB irradiation of cultured HLECs, indicating that EGCG may be able to protect HLECs against UVB damage.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway

Song

Gao

et al. 2022

Mol Med Rep

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Ganoderic Acid A Attenuates IL-1β-Induced Inflammation in Human Nucleus Pulposus Cells Through Inhibiting the NF-κB Pathway

Zheng

Zhao

et al. 2021

Inflammation

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Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

Cited by 7 publications

References 26 publications

Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway

Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway

Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway

Ganoderic Acid A Attenuates IL-1β-Induced Inflammation in Human Nucleus Pulposus Cells Through Inhibiting the NF-κB Pathway

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