2012
DOI: 10.1371/journal.pone.0040136
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Abstract: Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be a master cytokine in chronic, destructive arthritis. Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium of patients with RA. Based on the increased cytokine secretions observed in in vitro experiments, G… Show more

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Cited by 35 publications
(30 citation statements)
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“…Gangliosides are sialic acid-containing glycosphingolipids widely found in the plasma membrane of mammalian cells (Prokazova, Samovilova, Gracheva, & Golovanova, 2009). ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5) catalyzes the formation of the ganglioside GM3 (Tsukuda et al, 2012). GM3 initiates cellular responses including differentiation, membrane-related signaling, and apoptosis in numerous somatic and cancerous cells (Kwak, Seo, Chang, & Choo, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Gangliosides are sialic acid-containing glycosphingolipids widely found in the plasma membrane of mammalian cells (Prokazova, Samovilova, Gracheva, & Golovanova, 2009). ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ST3GAL5) catalyzes the formation of the ganglioside GM3 (Tsukuda et al, 2012). GM3 initiates cellular responses including differentiation, membrane-related signaling, and apoptosis in numerous somatic and cancerous cells (Kwak, Seo, Chang, & Choo, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Deer bone extract contains 1.03 mg/g of ganglioside (Table 2). Among GSLs, gangliosides, including GM3 and its derivatives, are related to arthritic diseases [373839]. In the context of OA, the total ganglioside content of OA cartilage is decreased by 40% [3738].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the gene expression of GM3S and the GM3 expression levels were higher in the synovia of patients with RA than with osteoarthritis . In GM3S −/− mice, the progression of collagen‐induced inflammatory arthritis, a mouse model of RA, was accelerated, and the induction of IL‐17‐producing cells in regional lymph nodes was enhanced by collagen immunization . In contrast, GM3S −/− mice exhibited a smaller number of Th17 cells after culture in vitro .…”
Section: Gangliosides In Adaptive Immunitymentioning
confidence: 98%
“…In RA patients, macrophages, Th1 cells, Th17 cells, and activated B cells migrates into inflamed tissues, and inflammatory cytokines, including IL‐1, IL‐6, IL‐8, IL‐17, TNFα, and interferon‐gamma, can be detected in the fluids surrounding inflamed synovia and joints . Moreover, the gene expression of GM3S and the GM3 expression levels were higher in the synovia of patients with RA than with osteoarthritis . In GM3S −/− mice, the progression of collagen‐induced inflammatory arthritis, a mouse model of RA, was accelerated, and the induction of IL‐17‐producing cells in regional lymph nodes was enhanced by collagen immunization .…”
Section: Gangliosides In Adaptive Immunitymentioning
confidence: 99%