Gamma knife radiosurgery for pituitary adenomas

Izawa, Masahiro; Hayashi, Motohiro; Nakaya, K.; Satoh, Hiroyuki; Ochiai, Taku; Hori, Tomokatsu; Takakura, Kintomo

doi:10.3171/jns.2000.93.supplement_3.0019

Cited by 107 publications

(52 citation statements)

References 4 publications

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“…Encouraged by these results, some Asian centers started to treat again patients primarily with radiosurgery. At median follow-up times of about 2 years, 40-100% of the patients achieve hormonal normalization [47,56,62,69,85,94]. Toxicity was very low in these series.…”

Section: Radiosurgerymentioning

confidence: 79%

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

Becker¹,

Köcher

Kortmann³

et al. 2002

Strahlentherapie und Onkologie

140

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Conventional radiation therapy of pituitary adenoma is highly effective. It is recommended after subtotal resection of primary tumors such as macroadenomas, after gross total resection from endocrine active adenomas with postsurgical hormone secretion and for recurrent tumors. Radiosurgery seems to be a possible treatment alternative in experienced centers, and only in patients with adenomas smaller than 25-30 mm with a minimum distance of 2-3 mm to the chiasm.

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Section: Radiosurgerymentioning

confidence: 79%

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

Becker¹,

Köcher

Kortmann³

et al. 2002

Strahlentherapie und Onkologie

140

View full text Add to dashboard Cite

show abstract

“…These cases may be both clinically asymptomatic and selfresolving [3,33]. Patients with prior irradiation appear to be more susceptible to radiation-induced brain necrosis [4,[33][34]. With current technological advancements of radiotherapy techniques, it is expected that the significant reduction of radiation treatment fields will translate into brain necrosis being a rare occurrence.…”

Section: Other Adverse Eventsmentioning

confidence: 94%

Radiation therapy in acromegaly

Shih

Loeffler

2007

Rev Endocr Metab Disord

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Radiation therapy is generally not a primary treatment modality for growth hormone-secreting pituitary adenomas. However, in patients with acromegaly refractory to medical and/or surgical interventions, radiation can offer durable tumor control and often biochemical remission. Technique of radiation therapy delivery and dose vary by adenoma size and extrasellar extension. Radiation can be delivered in a single sitting by stereotactic radiosurgery or in fractionated form of smaller doses delivered over typically 5-6 weeks in 25-30 treatments. A brief overview of forms of radiation modalities is reviewed followed by discussion of the role for radiation therapy, rationale of delivery method, and potential adverse effects.

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“…The reported results of GK SRS for non-functioning adenomas of 584 patients in 14 studies are shown in Table 2 [49][50][51][52][53][54][55][56][57][58][59][60][61][62][63]. Six studies reported actuarial PFS with a 5-year control rate in the region of 94% at a median follow up of 44 months and because of size restriction of SRS this usually refers to small residual tumours.…”

Section: Radiosurgery (Srs)mentioning

confidence: 96%

Modern techniques for pituitary radiotherapy

Minniti

Gilbert

Brada

2008

Rev Endocr Metab Disord

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Radiotherapy (RT) remains an effective treatment for residual or recurrent pituitary adenomas with excellent rates of tumour control and normalisation of excess hormone secretion. The main late toxicity is hypopituitarism: other side effects are rare. We discuss technical developments in the delivery of radiotherapy (stereotactic conformal radiotherapy (SCRT) and stereotactic radiosurgery (SRS)), all aiming to reduce the amount of normal brain receiving significant doses of radiation. We provide a comprehensive review of published data on outcome of conventional fractionated radiotherapy and modern RT techniques. SCRT is a suitable treatment technique for all sizes of pituitary adenoma and efficacy is comparable to conventional RT; the lack of long term follow up means that currently there is no information on potential reduction in the incidence of late radiation induced toxicity. Single fraction SRS can only be safely delivered to small tumours away from critical structures. There is no evidence that it produces faster decline of elevated hormone levels than fractionated treatment and is not associated with lesser morbidity.

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Gamma knife radiosurgery for pituitary adenomas

Cited by 107 publications

References 4 publications

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

Radiation therapy in acromegaly

Modern techniques for pituitary radiotherapy

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