Gamma benzene hexachloride toxicity: a review

The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane

“…Brain is proposed to be highly susceptible to oxidative stress because of its poor antioxidant defense and rich content of easily peroxidisable polyunsaturated fatty acids (PUFAs) [8]. Lindane in therapeutic doses used in the treatment of scabies has been found to have neurotoxic and other effects such as nausea and convulsions [9]. It is highly toxic to CNS, causing mental and motor retardation, CNS excitation, clonic and tonic convulsions, increased irritability and impair spontaneous and conditioned behaviour in rats.…”

c-fos and ornithine decarboxylase gene expression in brain as early markers of neurotoxicity

“…Lindane (y-hexachlorocyclohexane) is a potent and widely used organochlorine pesticide employed in veterinary and human medicine as an ectoparasiticide 25 • The compound is known to be able to cause hyperexcitability, tremors and convulsions in humans and other mammals 10 • 27 • 30 • 32 • Although it is uncertain by what mechanism lindane effects excitation, enhanced synaptic release of neurotransmitters 22 may be involved. It has been proposed that an increased level of intracellular calcium underlies this effect3 2 • 33 • Low level exposures (10-6 -10-7 M) to lindane increased 45 Ca uptake into isolated rat brain synaptosomes 9 • 20 • Direct measurement of free intrasynaptosomal Ca 2 + revealed that lindane increases [Ca 2 +]i in a dose-dependent manner3.…”

Levels of dichlorodiphenyltrichloroethane and hexachlorocyclohexane in human adipose tissue of the Indian population.

“…The fat was dissol ved in 50 ml of hexane, and 25 ml o f the hexane extract wa s subj ected to liquid: liquid extraction (7) with the The residues of organochlorine pesticides have received worldwide attention in the last few decades since studi es have shown an accumulation o f the se chemicals in the en vironment, and in human tissues as well (9,11,13,27). There are numerous reports concerning acute (12,19,25) and chronic (8,17,30) to xic effects o f pesticides in man . H igher residues of the se chemicals have been reported in patients suffering from diseases such as cirrhosis, atherosclerosis, hypertension , idiopathic amyl oidosis, and certain forms of can cer (6,22,26).…”