2020
DOI: 10.3389/fimmu.2020.580593
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Abstract: Gallic acid is an active phenolic acid widely distributed in plants, and there is compelling evidence to prove its anti-inflammatory effects. NLRP3 inflammasome dysregulation is closely linked to many inflammatory diseases. However, how gallic acid affects the NLRP3 inflammasome remains unclear. Therefore, in the present study, we investigated the mechanisms underlying the effects of gallic acid on the NLRP3 inflammasome and pyroptosis, as well as its effect on gouty arthritis in mice. The results showed that … Show more

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Cited by 121 publications
(63 citation statements)
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“…Therefore, the formation of vesicles identi ed in synoviocytes could be associated with the activation of pyroptosis, and in this sense, PGAL, by inhibiting the formation of these vesicles, would exert a possible mechanism of action through the inhibition of in ammasomes or of pyroptosis. Similar to its precursor, GA, which was studied in in vitro and in vivo models of gout [30], was shown to inhibit pyroptosis in macrophages stimulated by MSU, block the activation of NLRP3, inhibit caspase-1 activation and IL-1β secretion and promote the expression of factor 2 related to nuclear factor E2 (Nrf2), reducing mitochondrial ROS, which supports our hypothesis that a similar mechanism occurs for PGAL.…”
Section: Discussionsupporting
confidence: 79%
“…Therefore, the formation of vesicles identi ed in synoviocytes could be associated with the activation of pyroptosis, and in this sense, PGAL, by inhibiting the formation of these vesicles, would exert a possible mechanism of action through the inhibition of in ammasomes or of pyroptosis. Similar to its precursor, GA, which was studied in in vitro and in vivo models of gout [30], was shown to inhibit pyroptosis in macrophages stimulated by MSU, block the activation of NLRP3, inhibit caspase-1 activation and IL-1β secretion and promote the expression of factor 2 related to nuclear factor E2 (Nrf2), reducing mitochondrial ROS, which supports our hypothesis that a similar mechanism occurs for PGAL.…”
Section: Discussionsupporting
confidence: 79%
“…Nod-like receptor protein 3 (NLRP3) has been intensively investigated for its potential role in various human diseases ( Yang et al, 2019 ; Lin et al, 2020 ). The NLRP3 protein was also reported to play a vital role in activating and promoting of human cancers, including oral squamous cell carcinoma Wang et al (2018) , endometrial cancer Liu et al (2019) , and breast cancer ( Li et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%
“…GA was also confirmed to restore the antioxidant and inflammatory status to the normal levels via nuclear factor erythroid 2-related factor 2 (Nrf2) activation [ 53 , 54 ]. GA exerted its inhibitory effect on proptosis and NLRP3–NEK7 interaction dependent on the Nrf2 signaling [ 55 ]. GA could also modulate the ERK/Nrf2-induced antioxidative signaling pathway, and the potential mechanism showed that GA possibly competed with Nrf2 for binding to Keap1 [ 56 ].…”
Section: Mechanism Of Gallic Acid’s Antioxidant and Anti-inflammationmentioning
confidence: 99%