Gallbladder carcinoma

Miller, George; Jarnagin, William R.

doi:10.1016/j.ejso.2007.07.206

Cited by 193 publications

(162 citation statements)

References 44 publications

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“…The countries with a high incidence of gallbladder cancer include Chile, Poland, India and Japan. A very high incidence of this cancer has been reported among women in northern India (21.5/100,000) and among female Native American Indians (14.5/1000,000) [10].…”

Section: Discussionmentioning

confidence: 97%

Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Jetley¹,

Sabina²,

H³

et al. 2013

JCDR

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Background: Gall bladder carcinoma accounts for 98% of all the gall bladder malignancies and it is the sixth most common malignancy of the gastrointestinal tract worldwide. The incidence of incidental gall bladder carcinoma which is diagnosed during or after a laparoscopic cholecystectomy is reported to be around 0.19-3.3% in the literature.Aim: This study was aimed at detecting the incidence of gall bladder carcinomas which were diagnosed incidentally during or after laparoscopic cholecystectomies which were done for gall stone disease and cholecystitis. Materials and Methods:We analyzed the medical records of patients with symptomatic gallstone disease and acute or chronic cholecystitis, who underwent laparoscopic cholecystectomies at the Hakeem Abdul Hameed Centenary Hospital during the period from January 2007 to June 2012.Results: A total of 622 laparoscopic cholecystectomies were performed at our institute during the study period of five and a half years. In 6 (0.96%) cases, incidental carcinomas of the gallbladder were discovered. Conclusion:A laparoscopic cholecystectomy which is performed for benign gall bladder disease rarely results in a diagnosis of unexpected gallbladder cancer. The microscopic examination of the specimens, with special attention to the depth of invasion, range of the mucosal spread and the lymphovascular involvement, is critical in diagnosing the incidental malignancies as well as for the subsequent management of the cases.

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Section: Discussionmentioning

confidence: 97%

Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Jetley¹,

Sabina²,

H³

et al. 2013

JCDR

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“…GBC is discovered incidentally during histopathology following 0.25-3.0% of laparoscopic cholecystectomies [3][4][5][6]; however, this constitutes 74-92% of all GBC diagnoses [7,8]. Although rare, GBC is the most common malignant disease of the biliary tract [9].…”

Section: Incidence and Prevalencementioning

confidence: 99%

“…The increase in cost and pathologists' workload due to evaluation of specimens from the most commonly performed surgery worldwide remains debatable. Yet, this practice might result in diagnosis of GBC in 0.25-3.0% of all samples evaluated [3][4][5][6]. Some studies recommend selective histological examination of the gallbladder on the basis of red lags in the perioperative period, on radiological imaging, and on macroscopic examination of the gallbladder.…”

Section: Importance Of Postoperative Pathological Evaluation Followinmentioning

confidence: 99%

Incidental Gallbladder Cancer

Al-Alem¹,

Mattar²,

Madkhali³

et al. 2017

Updates in Gallbladder Diseases

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Gallbladder cancer (GBC) is a rare but fatal disease with an incidence of less than 5000 new cases per year in the United States. Less than 20% of GBC cases are diagnosed preoperatively. The remaining cases are diagnosed either after laparoscopic cholecystectomy or intraoperatively. GBC is discovered incidentally during histopathology following 0.25-3.0% of laparoscopic cholecystectomies; however, this constitutes 74-92% of all GBC. The most pivotal and important step is accurate patient staging. Staging dictates disease management and treatment options and predicts survival. Because of the fatality of GBC and its poor prognosis, atempts of curative surgery are limited to localized resectable disease.

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“…It is a rare malignancy in most of the world contributing to just 4 % of gastrointestinal cancers. However there is a very high incidence of this cancer among women in Northern India (21.5/100,000) [2]. Carcinoma Gall bladder is an aggressive disease with late presentation, rapid progression, early recurrence,and dismal outcome.…”

Section: Introductionmentioning

confidence: 99%

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

Selvakumar

Zaidi

Pande

et al. 2015

Indian J Surg Oncol

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Although rare over most of the world, Gallbladder cancer is very common in northern india. A delayed presentation, aggressive nature,lack of randomised trials and a poor prognosis have all contributed to the nihilistic halo encircling gallbladder cancer. None of the advances in oncology have been exploited enough to shatter the nihilistic halo. In this background we sought to analyze if the addition of neoadjuvant chemotherapy had any impact on the resectability, overall and disease free survival in patients with advanced carcinoma of the gallbladder. We reviewed the records of all patients who underwent surgery for carcinoma of the gall bladder from 2004 to 2010 at our institute retrospectively. Twenty-one patients received neoadjuvant chemotherapy and subsequently taken up for surgery. Outcome analysis of these 21 patients were done by Kaplan meier method and graphs plotted. Out of the 21 patients who were taken up for surgery after neoadjuvant chemotherapy, fourteen patients underwent R0 resection (Group 1). Seven patients had been rendered inoperable on exploration (Group 2). Thus about 66.67 % of patients deemed resectable after neoadjuvant chemotherapy on imaging underwent R0 resection. The mean overall survival of the group 1 was 42.8 months versus 6.6 months of group 2(Hazard Ratio: 3.42). Neoadjuvant chemotherapy improves resectability in some patients with unresectable gall bladder cancer. Resection after neoadjuvant chemotherapy is feasible and may improve survival in a select group of patients. However randomized studies are required to establish its definitive role.

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Gallbladder carcinoma

Cited by 193 publications

References 44 publications

Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Incidental Gallbladder Cancer

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

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