Galectins in Glioma: Current Roles in Cancer Progression and Future Directions for Improving Treatment

Ajarrag, Samy; St‐Pierre, Yves

doi:10.3390/cancers13215533

Cited by 4 publications

(1 citation statement)

References 148 publications

(165 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A surprising finding in this study was the expression pattern of GAL-3, a chimera-type galectin with myriad functions [ 42 ]. We previously observed a marked increase in GAL-3 expression in canine astrocytomas [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation

Toedebusch,

Wei,

Simafranca

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

The goal of this study was to define the glioma-associated microglia/macrophage (GAM) response and associated molecular landscape in canine oligodendrogliomas. Here, we quantified the intratumoral GAM density of low- and high-grade oligodendrogliomas compared to that of a normal brain, as well as the intratumoral concentration of several known GAM-derived pro-tumorigenic molecules in high-grade oligodendrogliomas compared to that in a normal brain. Our analysis demonstrated marked intra- and intertumoral heterogeneity of GAM infiltration. Correspondingly, we observed significant variability in the intratumoral concentrations of several GAM-associated molecules, unlike what we previously observed in high-grade astrocytomas. However, high-grade oligodendroglioma tumor homogenates (n = 6) exhibited an increase in the pro-tumorigenic molecules hepatocyte growth factor receptor (HGFR) and vascular endothelial growth factor (VEGF), as we observed in high-grade astrocytomas. Moreover, neoplastic oligodendrocytes displayed robust expression of GAL-3, a chimeric galectin implicated in driving immunosuppression in human glioblastoma. While this work identifies shared putative therapeutic targets across canine glioma subtypes (HGFR, GAL-3), it highlights several key differences in the immune landscape. Therefore, a continued effort to develop a comprehensive understanding of the immune microenvironment within each subtype is necessary to inform therapeutic strategies going forward.

show abstract

Section: Discussionmentioning

confidence: 99%

Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation

Toedebusch,

Wei,

Simafranca

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

Protein - carbohydrate interaction studies using domestic animals as role models support the search of new glycomimetic molecules

Zhang,

Li,

Mohri

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma

Batchu,

Hanafy,

Redjal

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Glioblastoma (GBM) is an aggressive primary CNS malignancy and clinical outcomes have remained stagnant despite introduction of new treatments. Understanding the tumor microenvironment (TME) in which tumor associated macrophages (TAMs) interact with T cells has been of great interest. Although previous studies examining TAMs in GBM have shown that certain TAMs are associated with specific clinical and/or pathologic features, these studies used an outdated M1/M2 paradigm of macrophage polarization and failed to include the continuum of TAM states in GBM. Perhaps most significantly, the interactions of TAMs with T cells have yet to be fully explored. Our study uses single-cell RNA sequencing data from adult IDH-wildtype GBM, with the primary aim of deciphering the cellular interactions of the 7 TAM subtypes with T cells in the GBM TME. Furthermore, the interactions discovered herein are compared to IDH-mutant astrocytoma, allowing for focus on the cellular ecosystem unique to GBM. The resulting ligand-receptor interactions, signaling sources, and global communication patterns discovered provide a framework for future studies to explore methods of leveraging the immune system for treating GBM.

show abstract

Galectins in Glioma: Current Roles in Cancer Progression and Future Directions for Improving Treatment

Cited by 4 publications

References 148 publications

Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation

Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation

Protein - carbohydrate interaction studies using domestic animals as role models support the search of new glycomimetic molecules

Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma

Contact Info

Product

Resources

About