Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor

Sasaki, Takaya

doi:10.1093/glycob/cwh043

Cited by 63 publications

(48 citation statements)

References 37 publications

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“…It has been reported that galectin-1 induces brain derived neurotrophic factor (BDNF) in astrocytes. 31 Furthermore, it was also reported that BDNF promotes adult neurogenesis. 3,32 Astrocytes expressing galectin-1 may thus increase the supply of such neurotrophic factors to promote neurogenesis after brain insults.…”

Section: Discussionmentioning

confidence: 99%

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

et al. 2008

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We examined the expression of galectin-1, an endogenous lectin with one carbohydrate-binding domain, in the adult mouse hippocampus after systemic kainate administration. We found that the expression of galectin-1 was remarkably increased in activated astrocytes of the CA3 subregion and dentate gyrus of the hippocampus, and in nestin-positive neural progenitors in the dentate gyrus. Quantitative reverse transcription PCR (RT-PCR) analysis revealed that the galectin-1 mRNA level in hippocampus began to increase 1 day after kainate administration and that a 13-fold increase was attained within 3 days. Western blotting analysis confirmed that the level of galectin-1 protein increased to more than three-fold a week after the exposure. We showed that isolated astrocytes express and secrete galectin-1. To clarify the significance of the increased expression of galectin-1 in hippocampus, we compared the levels of hippocampal cell proliferation in galectin-1 knockout and wild-type mice after saline or kainate administration. The number of 5-bromo-2 0 -deoxyuridine (BrdU)-positive cells detected in the subgranular zone (SGZ) of galectin-1 knockout mice decreased to 62% with saline, and to 52% with kainate, as compared with the number seen in the wild-type mice. Most of the BrdU-positive cells in SGZ expressed doublecortin and neuron-specific nuclear protein, indicating that they are immature neurons. We therefore concluded that galectin-1 promotes basal and kainateinduced proliferation of neural progenitors in the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

et al. 2008

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“…There are several reports in the literature suggesting that astrocytes are capable of BDNF production in response to various stimuli (Miklic et al 2004;Sasaki et al 2004;Toyomoto et al 2004;Wu et al 2004;Aharoni et al 2005). One of these studies (Miklic et al 2004) reported the neutral effect of TNF-α on astroglial BDNF regulation.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine

Saha

Liu

Pahan

2006

Jrnl Neuroimmune Pharm

230

170

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Tumor necrosis factor-alpha (TNF-α) is widely known to be involved in physiological and pathophysiological processes of the brain where this proinflammatory cytokine is implicated with regulation of inflammatory and survival components. We report that TNF-α up-regulates exon-IVbdnf mRNA and brain-derived neurotrophic factor (BDNF) protein in primary astrocytes. The BDNF protein was detectable both in cellular lysate and in the extracellular medium. Activation of NF-κB by TNF-α and inhibition of TNF-α-induced BDNF expression by Δp65 (a dominant-negative mutant) and NEMO-binding domain peptide (an inhibitor of NF-κB) suggests that TNF-α induces BDNF expression through the activation of NF-κB. Similarly, TNF-α induced the activation of C/EBPβ and the expression of BDNF was sensitive to overexpression of ΔC/EBPβ (a dominant-negative mutant) and ETO (an inhibitor of C/EBPβ). Among three MAP kinases, TNF-α-induced BDNF up-regulation was sensitive only to inhibitors of ERK MAP kinase. However, the ERK MAP kinase pathway was coupled to activation of C/EBPβ but not NF-κB. Taken together, this study identifies a novel property of TNF-α in inducing the expression of BDNF via NF-κB and C/EBPβ in astrocytes that may be responsible for neurotrophic activity of the cytokine.

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“…2D) and TAs [18]. Together, these results [30,37] Schwan cells + [24,25] Migration after injury (Ox) [24,30] Red nucleus complex + [22] Cerebellum Neurons + + [26] Glial cells + + [26] Differentiation (R) [32] Forebrain Neurons + + [27] SVZ astrocytes + [18] Proliferation (R) [18] Olfactory bulb Sensory neurons + + + [28] Neurite growth and/or pathfinding (R) [31] Mitral cells + + [28] 2nd order projection neurons + [28] Interneurons + [28] Non neuronal cells + [29] 1256 M. Sakaguchi, Y. Imaizumi and H. Okano Galectin-1 in neural stem cells indicate that Gelectin-1 promotes the proliferation of adult NSCs.…”

Section: Galectin-1 Promotes the Proliferation Of Adult Nscsmentioning

confidence: 91%

Expression and function of galectin-1 in adult neural stem cells

Sakaguchi

Imaizumi

2007

Cell. Mol. Life Sci.

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Neural stem cells (NSCs) in the adult mammalian brain proliferate and continuously produce new neurons. To date, there has been little research into the functions of lectins in adult NSCs. Recently, we reported that a lectin, galectin-1, is expressed on adult NSCs and promotes their proliferation through its carbohydrate-binding ability. This evidence raises the possibility that glycans play roles in the proliferation of adult NSCs.

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Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor

Cited by 63 publications

References 37 publications

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus

Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine

Expression and function of galectin-1 in adult neural stem cells

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