2001
DOI: 10.1016/s0002-9440(10)63982-x
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Abstract: Although several genes/genetic loci involved in the etiology of Wilms' tumor have been identified, little is known of the molecular changes associated with relapse. We therefore undertook an analysis by comparative genomic hybridization (CGH) of 58 tumor samples of favorable histology Wilms' tumor taken at initial diagnosis and/or relapse. Tumors with anaplastic histology were excluded as this is known to be associated with p53 mutation and a poor prognosis. A control group of 21 Wilms' tumors that did not rel… Show more

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Cited by 127 publications
(114 citation statements)
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“…A loss of 1q was also detected in about 15% of papillary RCCs (Jiang et al, 1998;Reutzel et al, 2001) and in less than 10% of clear cell RCCs . In Wilms tumors, 1q gain was described to be a predominant alteration in comparative genomic hybridization analyses (Hing et al, 2001). Interestingly, LOH at loci 1q21-22 and 1q32 has been also associated with tumor adverse outcome (Law et al, 1997;Natrajan et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…A loss of 1q was also detected in about 15% of papillary RCCs (Jiang et al, 1998;Reutzel et al, 2001) and in less than 10% of clear cell RCCs . In Wilms tumors, 1q gain was described to be a predominant alteration in comparative genomic hybridization analyses (Hing et al, 2001). Interestingly, LOH at loci 1q21-22 and 1q32 has been also associated with tumor adverse outcome (Law et al, 1997;Natrajan et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…1 and 3), justifying its further assessment as a prognostic marker in children. The gain of chromosome 1q is associated with an unfavorable outcome in Wilms' tumors, neuroblastomas, and Ewing's sarcomas, which suggests a generic role in pediatric tumor progression and recurrence (143)(144)(145). Conventional cytogenetics suggests that 1q gain results from a variety of unbalanced rearrangements with material from numerous partner chromosomes rather than a single, recurrent translocation (43,44).…”
Section: Immunohistochemical and Genomic Markersmentioning
confidence: 99%
“…Future Children's Oncology Group (COG) clinical studies will augment therapy for patients with favorable histology Wilms' tumor and LOH at 1p and 16q. Other promising prognostic markers are an increase in gene copy number or expression at chromosome 1q [28,29] and telomerase expression level [30,31]. Gene expression profiling also shows promise to identify new prognostic factors [32][33][34].…”
Section: Biological Prognostic Factorsmentioning
confidence: 99%