Gadolinium-doped carbon dots as a ratiometric fluorometry and colorimetry dual-mode nano-sensor based on specific chelation for morin detection

Wang, Huiping; Xing, Huaizhong; Liu, Wei; Hao, Yumin; Zhang, Li; Yang, Zhenhua; Hu, Qin; Shuang, Shaomin; Dong, Chuan; Gong, Xiaojuan

doi:10.1016/j.snb.2021.130991

Cited by 31 publications

(14 citation statements)

References 44 publications

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“…This property increases interest in the development of methodologies that allow for the detection and quantification of foods, drugs, and natural products, especially when MR is used as a new natural medicine for effective cancer treatments [ 2 ]. Some reports for MR detection have used techniques such as fluorescence [ 3 , 4 , 5 , 6 ] and HPLC [ 7 ]. According to these reports, the detection limits are very sensitive, between 0.04 and 0.6 µmol/L, and are applied in biological samples and natural products.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of Morin in Natural Food Using a Chitosan–Graphene Glassy Carbon Modified Electrode

Nagles

Bello²,

Hurtado³

2022

Sensors

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This report presents a new application for the chitosan–graphene glassy carbon electrode (Ch-G/GCE) system in the determination of the hydroxyflavonoid morin (MR), one of the flavonoids with the highest favorable activity for people, due to its natural properties by square-wave voltammetry (SWV). The anodic peak current for MR was observed at 0.50 V with an increase of 73% compared with the glassy carbon electrode unmodified. The surface areas of Ch-G/GCE, Ch/GCE and GCE evaluated by cyclic voltammetry were 0.140, 0.053 and 0.011 cm2, respectively. Additionally, an increase greater than 100% compared to the electrode without modification was observed. The detection limit was 0.30 µmol/L for MR, and the relative standard deviations (RSDs) were 1.8% (n = 6). Possible interferences as quercetin, rutin, and applications in real samples were also evaluated with very acceptable results.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of Morin in Natural Food Using a Chitosan–Graphene Glassy Carbon Modified Electrode

Nagles

Bello²,

Hurtado³

2022

Sensors

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“…in 2004, [23] great efforts have been made to regulate their structures and properties, aiming at improving the photoluminescent quantum yield, broadening the photoluminescence spectral coverage, and endowing CDs with special applications [24–29] . Metal ion‐doping is an effective approach to tune the physicochemical properties of nanomaterials due to the extensive free electrons, unoccupied orbitals, and large atomic radius of metal ions [30–34] . CDs have abundant electronic energy levels, and have been verified to be excellent electron donors or acceptors in many previous studies [35] .…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26][27][28][29] Metal iondoping is an effective approach to tune the physicochemical properties of nanomaterials due to the extensive free electrons, unoccupied orbitals, and large atomic radius of metal ions. [30][31][32][33][34] CDs have abundant electronic energy levels, and have been verified to be excellent electron donors or acceptors in many previous studies. [35] As expected, the doping of CDs with metal ions greatly changes the electronic distribution and the energy gap of CDs, and thus brings noticeable alterations in photophysical, magnetic, and electronic properties.…”

Section: Introductionmentioning

confidence: 99%

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Qian

et al. 2022

ChemMedChem

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Metal ions possess abundant electrons and unoccupied orbitals, as well as large atomic radii, whose doping into carbon dots (CDs) is a facile strategy to endow CDs with additional physicochemical characteristics. After being doped with metal ions, CDs reveal obvious changes in their optical, electronic, and magnetic properties by adjustments to their electron density distribution and the energy gaps, leading them to be promising and competitive candidates as labeling probes, imaging agents, catalysts, nanodrugs, and so on. In this review, we summarize the fabrication methods of metal‐ion‐doped CDs (M‐CDs), and highlight their biological applications including biosensing, bioimaging, tumor therapy, and anti‐microbial treatment. Finally, the challenging future perspectives of M‐CDs are analyzed. We hope this review will provide inspiration for further development of M‐CDs in various biological aspects, and help readers who are interested in M‐CDs and their biological applications.

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“…In this regard, several fluorometric sensors have been developed based on CQDs to determine various chemical and biochemical species such as metal ions, drugs, water pollutants, and proteins, to name a few. ,− Due to the sensitivity of the CQDs in sensing applications and the importance of monitoring medication uptake, drug detection is one of the appealing branches of CQD-based fluorometric sensors. − For instance, Feng et al have used nitrogen-doped CQDs functionalized with molecularly imprinted polymers for doxycycline determination based on fluorescence quenching. In another study, the fluorescence resonance energy transfer (FRET) mechanism was used to detect the gemcitabine drug via silver nanoparticle–CQD nanocomplex by Shekarbeygi and colleagues .…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

Saboorizadeh

Zare‐Dorabei

2022

ACS Biomater. Sci. Eng.

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, an immunosuppressive drug, has been widely prescribed for treating leukemia and autoimmune diseases. The level of the 6-MP drug in body fluids is of great interest due to the severe health problems related to its overdose. This study used a facile microwave preparation route to synthesize carbon quantum dots (CQDs) using glutathione and formamide as carbon sources. The obtained monodispersed quantum dots showed dual fluorescence emission with a sensitive affinity toward the 6-MP drug. The sensor's response was optimized by tuning the temperature, pH, and volume ratio of the probe. The prepared ratiometric fluorescence method showed accurate measurements for determining mercaptopurine in aqueous solutions in the concentration range of 1.4−7.6 mg L −1 with the limit of detection of 1.3 mg L −1 . The sensor's performance was assessed in complex solutions, human urine, and human plasma sample and recovery values in the range of 88− 127% were obtained. The reliable dual fluorometric sensor showed promising results for 6-MP determination and potential application for the determination of other chemical and biochemical species.

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Gadolinium-doped carbon dots as a ratiometric fluorometry and colorimetry dual-mode nano-sensor based on specific chelation for morin detection

Cited by 31 publications

References 44 publications

Electrochemical Determination of Morin in Natural Food Using a Chitosan–Graphene Glassy Carbon Modified Electrode

Electrochemical Determination of Morin in Natural Food Using a Chitosan–Graphene Glassy Carbon Modified Electrode

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

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