GABA receptor multiplicityVisualization of different receptor types in the mammalian CNS

Bowery, Norman G.; Price, G. W.; Hudson, Alan L.; Hill, David R.; Wilkin, Graham P.; Turnbull, M J

doi:10.1016/0028-3908(84)90063-7

Cited by 293 publications

(71 citation statements)

References 32 publications

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“…The acid secretagogue response to PCPGABA was more potent than that in response to histamine or bethanechol (9). Muscimol, an agonist acting selectively at bicuculline-sensitive GABAA receptor sites (25), also caused an activation in vagal efferent transmission more rapidly than PCPGABA, followed by gastric hypersecretion which is in accordance with previous findings using pylorus ligated rats (26). Although the degrees of their effects on vagal activities were almost the same, PCPGABA was a more potent secretagogue than muscimol.…”

Section: Discussionsupporting

confidence: 90%

GABAA and GABAB-receptor agonists evoked vagal nerve efferent transmission in the rat.

Yamasaki

Gotō

Hara³

et al. 1991

Jpn.J.Pharmacol

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ABSTRACT-The effect of GABA agonists on vagal efferent activity was studied in anesthetized rats. PCPGABA, a GABAB agonist (4 and 8 mg/kg, s.c.), markedly activated the neural efferent discharge of the vagus. Muscimol, a GABAA agonist (0.1 and 0.3 mg/kg, i.v.), also facilitated vagal activity. Both agonists caused significant gastric acid hyperacidity. Bicuculline (0.25 mg/kg, i.v.) or picrotoxin (0.5 mg/kg, i.v.) given 10 min prior to each agonist had no effect on the frequency of vagal nerve firing elicited by PCPGABA (4 mg/kg, s.c.) or muscimol (0.3 mg/kg, i.v.). Pretreatment with scopolamine (0.25 mg/kg, i.v.) abolished PCPGABA stimulated vagal activity and gastric acid secretion. Methscopolamine (0.25 mg/kg, i.v.) inhibited only the hyperacidity evoked by PCPGABA, but not vagal activation. These results suggest that PCPGABA and muscimol may cause gastric acid secretion through central cholinergic descending mechanisms that are resistant to GABAA and GABAB antagonists.

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Section: Discussionsupporting

confidence: 90%

GABAA and GABAB-receptor agonists evoked vagal nerve efferent transmission in the rat.

Yamasaki

Gotō

Hara³

et al. 1991

Jpn.J.Pharmacol

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“…How- ever, recent evidence indicates that the 1 subunit is able to assemble with the GABA A receptor 2 subunit in the brain and spinal cord to form a novel hybrid GABA receptor/channel (19 -21). The pharmacological and electrophysiological properties of the hybrid receptor/channel are very likely distinct from those of the GABA A and GABA C receptor/channels (19), further increasing the functional diversity of the ionotropic GABA receptor/channel in CNS (48). These discoveries suggest that 1 subunits may be a unique component of GABA receptor/channel heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Function of γ-Aminobutyric Acid Receptor/Channel ρ1 Subunits In Spinal Cord

Zheng

Xie

Zhang

et al. 2003

Journal of Biological Chemistry

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␥-Aminobutyric acid (GABA) receptor/channel 1 subunits are important components in inhibitory pathways in the central nervous system. However, the precise locations and roles of these receptors in the central nervous system are unknown. We studied the expression localization of GABA receptor/channel 1 subunit in mouse spinal cord and dorsal root ganglia (DRG). The immunohistochemistry results indicated that GABA receptor/channel 1 subunits were expressed in mouse spinal cord superficial dorsal horn (lamina I and lamina II) and in DRG. To understand the functions of the GABA receptor/channel 1 subunit in these crucial sites of sensory transmission in vivo, we generated GABA receptor/ channel 1 subunit mutant mice (rho1 ؊/؊ ). GABA receptor/channel 1 subunit expression in the rho1 ؊/؊ mice was eliminated completely, whereas the gross neuroanatomical structures of the rho1 ؊/؊ mice spinal cord and DRG were unchanged. Electrophysiological recording showed that GABA-mediated spinal cord response was altered in the rho1 ؊/؊ mice. A decreased threshold for mechanical pain in the rho1 ؊/؊ mice compared with control mice was observed with the von Frey filament test. These findings indicate that the GABA receptor/ channel 1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo.

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“…Indeed, the facilitatory effects of bicuculline on neuronal firing or neurotransmitter release has been interpreted as evidence of the involvement of GABA as a transmitter in the tonic modulation of CNS activity (Willette et al, 1984). The effect of bicuculline on peripheral neurotransmission in the autonomic nervous system is less well-known although morphological and functional evidence for a GABA involvement in the neuronal modulation at autonomic synapses is accumulating (Bowery et al, 1984). In particular it has been suggested that GABA plays a role as a neurotransmitter at the autonomic synapses of the gastrointestinal tract (Jessen et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

A facilitatory effect of bicuculline on the enteric neurones in the guinea‐pig isolated colon

Frigo

Galli

Lecchini

et al. 1987

British J Pharmacology

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Changes in the efficiency of the peristaltic reflex, acetylcholine (ACh) output and motor responses to transmural and periarterial nerve stimulation produced by bicuculline and -y-aminobutyric acid (GABA) receptor desensitization were investigated in the guinea-pig isolated colon. 2 Bicuculline, at concentrations unable to affect spontaneous colonic motility and lacking anticholinesterase activity, produced a dose-dependent increase of both the efficiency of the peristaltic reflex and the stimulated ACh output. Such effects could not be observed in GABA-desensitized preparations. 3 A frequency-dependent potentiation of the cholinergic excitatory and non-adrenergic noncholinergic (NANC) inhibitory responses to transmural stimulation was also observed in the presence of bicuculline. Conversely bicuculline exhibited an inhibitory effect on the relaxation induced by periarterial nerve stimulation. 4 Acute GABA-desensitization was unable to affect the contractile responses to transmural stimulation, the ACh output and the efficiency of the peristaltic reflex. On the contrary, desensitization was able to mimic the effects of bicuculline on the inhibitory responses to both transmural and periarterial nerve stimulation. 5 Our results are consistent with a significant role played by an intrinsic GABAergic pathway in the modulation of both cholinergic excitatory and NANC inhibitory neurones. The hypothesis is advanced that a feed-back modulation carried out through bicuculline-sensitive GABAergic synapses could operate during the propagation of peristaltic motor activity.

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GABA receptor multiplicityVisualization of different receptor types in the mammalian CNS

Cited by 293 publications

References 32 publications

GABAA and GABAB-receptor agonists evoked vagal nerve efferent transmission in the rat.

GABAA and GABAB-receptor agonists evoked vagal nerve efferent transmission in the rat.

Function of γ-Aminobutyric Acid Receptor/Channel ρ1 Subunits In Spinal Cord

A facilitatory effect of bicuculline on the enteric neurones in the guinea‐pig isolated colon

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