GABA and glutamate levels in occlusal splint-wearing males with possible bruxism

Decreased γ‐aminobutyric acid levels in the brainstem in patients with possible sleep bruxism: A pilot study

“…Clonazepam, a benzodiazepine receptor agonist, strengthens the binding between GABA and its receptor, thereby promoting the opening of chloride channels to induce cell polarisation and enhance the synaptic inhibition mediated by GABA neurons, thereby decreasing the excitability of the affected neurons. A separate MRS study performed in SB patients identified disturbances in the GABAergic and glutamatergic systems in potential SB patients and abnormal neurochemical levels in the dorsolateral prefrontal cortex . Restless legs syndrome (RLS) is comorbid with clenching and teeth‐grinding activities.…”

“…Some drugs, such as gabapentin, tiagabine, gamma‐hydroxybutyrate and diazepam, have been shown to ameliorate the manifestations of SB, suggesting that γ‐aminobutyric acid (GABA) may be critically important to SB development . Data from magnetic resonance spectroscopy (MRS) measurements of neurochemicals levels in SB patients have also demonstrated that these patients exhibit disturbances in GABAergic and glutamatergic systems . GABA is the main inhibitory neurotransmitter in the central nervous system (CNS), and it plays a vital role in regulating the performance of movement.…”

“…Glutamate (Glu) is a major excitatory neurotransmitter, and glutamine (Gln) is the active transport that recycles Glu. Glx (Glx = Glu + Gln) is a term that is widely used to describe glutamatergic metabolism . The MEGA‐Point Resolved Spectroscopy (MEGA‐PRESS) method has been used to specifically determine the levels of GABA and Glx in the brain .…”

“…Glx (Glx = Glu + Gln) is a term that is widely used to describe glutamatergic metabolism . The MEGA‐Point Resolved Spectroscopy (MEGA‐PRESS) method has been used to specifically determine the levels of GABA and Glx in the brain . In this study, with the aim of substantially improving our understanding of whether the subcortical and cortical networks that may affect the central masticatory pathways are under the genesis of SB, CMA and brainstem were chosen to identifying the regional alterations in GABA and Glx levels.…”

Bruxism and Current Treatment Approaches

“…Bazı çalımalarda pediatrik popülasyonda %120, yetikin popülasyonunda %58 iken geriatrik popülasyonda da %3'lük artı gösterdiği belirtilmitir. Cinsiyetler arasında farklılık saptanmamıtır 25 . Fonseca ve arkadaları, 170 çocuk ile yaptıkları kesitsel çalımada bruksizmin %91.42 oranında olduğunu gözlemlemitir 26 .…”