GABA and feeding: Reversal of overeating by central GABA-transaminase inhibition

Proteomic changes in the hypothalamus and retroperitoneal fat from male F344 rats subjected to repeated light–dark shifts

“…Second, the increased expression of gamma-amino butyric acid (GABA) aminotransferase corresponds to the role of the brain GABA mechanism in the control of food intake in rats. Elevations of brain GABA induced by intracisternal injection of the GABA aminotransferase inhibitor produced dose-dependent anorexia in both normal and obese rats [49][50][51]. Thus, upregulation of GABA aminotransferase in the HT suggests attenuated brain GABA levels, and thus, an enhanced appetite; this corresponds to increased food intake in the LS rat group.…”

Proteomic changes in the hypothalamus and retroperitoneal fat from male F344 rats subjected to repeated light–dark shifts

“…Second, the increased expression of gamma-amino butyric acid (GABA) aminotransferase corresponds to the role of the brain GABA mechanism in the control of food intake in rats. Elevations of brain GABA induced by intracisternal injection of the GABA aminotransferase inhibitor produced dose-dependent anorexia in both normal and obese rats [49][50][51]. Thus, upregulation of GABA aminotransferase in the HT suggests attenuated brain GABA levels, and thus, an enhanced appetite; this corresponds to increased food intake in the LS rat group.…”

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

“…Then, a combination of baclofen and naltrexone is a vital pharmacological strategy for BE and food addiction, as both of these medications are used for alcohol dependence [ 319 ] and other addictions [ 26 ]. Selectively targeting GABA B and opioid receptors has significant effects in suppressing overeating of palatable foods, high‐fat diets and food craving [ 64 , 320 ]. From a neurobiological perspective, activation of GABA B Rs seems to regulate only high‐fat diet or high‐calorie intake, and the underlying mechanisms are still unclear (Figure 4 and Table 3 ).…”

“…Additionally, GABA B Rs [ 64 , 320 ] and D2Rs [ 303 , 304 ] are dysfunctional in animals with a history of BE fat and sucrose. Activation of GABA B Rs reduced fat intake, had no effect on sucrose intake, and either stimulated or had no significant effect on chow intake, and these effects were further verified in a GABA B R knockout animal model [ 64 ].…”

Proteomic changes in the hypothalamus and retroperitoneal fat from male F344 rats subjected to repeated light–dark shifts

“…Second, the increased expression of gamma-amino butyric acid (GABA) aminotransferase corresponds to the role of the brain GABA mechanism in the control of food intake in rats. Elevations of brain GABA induced by intracisternal injection of the GABA aminotransferase inhibitor produced dose-dependent anorexia in both normal and obese rats [49][50][51]. Thus, upregulation of GABA aminotransferase in the HT suggests attenuated brain GABA levels, and thus, an enhanced appetite; this corresponds to increased food intake in the LS rat group.…”

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

“…Then, a combination of baclofen and naltrexone is a vital pharmacological strategy for BE and food addiction, as both of these medications are used for alcohol dependence [ 319 ] and other addictions [ 26 ]. Selectively targeting GABA B and opioid receptors has significant effects in suppressing overeating of palatable foods, high‐fat diets and food craving [ 64 , 320 ]. From a neurobiological perspective, activation of GABA B Rs seems to regulate only high‐fat diet or high‐calorie intake, and the underlying mechanisms are still unclear (Figure 4 and Table 3 ).…”

“…Additionally, GABA B Rs [ 64 , 320 ] and D2Rs [ 303 , 304 ] are dysfunctional in animals with a history of BE fat and sucrose. Activation of GABA B Rs reduced fat intake, had no effect on sucrose intake, and either stimulated or had no significant effect on chow intake, and these effects were further verified in a GABA B R knockout animal model [ 64 ].…”

Proteomic changes in the hypothalamus and retroperitoneal fat from male F344 rats subjected to repeated light–dark shifts

“…Second, the increased expression of gamma-amino butyric acid (GABA) aminotransferase corresponds to the role of the brain GABA mechanism in the control of food intake in rats. Elevations of brain GABA induced by intracisternal injection of the GABA aminotransferase inhibitor produced dose-dependent anorexia in both normal and obese rats [49][50][51]. Thus, upregulation of GABA aminotransferase in the HT suggests attenuated brain GABA levels, and thus, an enhanced appetite; this corresponds to increased food intake in the LS rat group.…”

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

“…Then, a combination of baclofen and naltrexone is a vital pharmacological strategy for BE and food addiction, as both of these medications are used for alcohol dependence [ 319 ] and other addictions [ 26 ]. Selectively targeting GABA B and opioid receptors has significant effects in suppressing overeating of palatable foods, high‐fat diets and food craving [ 64 , 320 ]. From a neurobiological perspective, activation of GABA B Rs seems to regulate only high‐fat diet or high‐calorie intake, and the underlying mechanisms are still unclear (Figure 4 and Table 3 ).…”

“…Additionally, GABA B Rs [ 64 , 320 ] and D2Rs [ 303 , 304 ] are dysfunctional in animals with a history of BE fat and sucrose. Activation of GABA B Rs reduced fat intake, had no effect on sucrose intake, and either stimulated or had no significant effect on chow intake, and these effects were further verified in a GABA B R knockout animal model [ 64 ].…”