G71R mutation of the UGT1A1 gene is not associated with neonatal hyperbilirubinemia in India

D’Silva, Selma Z.; Colah, Roshan; Ghosh, Kanjaksha; Mukherjee, Malay B.

doi:10.3109/14767058.2011.644362

Cited by 4 publications

(2 citation statements)

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“…Contrary to these findings, in the present study, G211A was observed only in 13 (11%) and 12 (8%) cases and controls, respectively, in the heterozygote state and did not have affect unconjugated bilirubin levels, which is concordant to the earlier observations made by D'Silva et al. () in neonates and Farheen et al. () in adults.…”

Section: Discussionsupporting

confidence: 88%

Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults

Chiddarwar

D’Silva

Colah

et al. 2016

Annals of Human Genetics

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Section: Discussionsupporting

confidence: 88%

Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults

Chiddarwar

D’Silva

Colah

et al. 2016

Annals of Human Genetics

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“…Therefore, neonates carrying the G71R UGT1A1 variant may be at risk for hyperbilirubinemia [ 18 ]. However, some studies found no effect of the polymorphism [ 36 , 39 ] Therefore, the mechanism of the G71R polymorphism requires further research [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Neonatal Hyperbilirubinemia with UGT1A1 Gene Polymorphisms: A Meta-Analysis

Zhu

Wang

et al. 2015

Med Sci Monit

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BackgroundThe results of studies on association between the polymorphisms in the coding region and the promoter of uridine diphosphateglucuronosyl transferase 1A1 (UGT1A1) and neonatal hyperbilirubinemia are controversial. This study aimed to determine whether the UGT1A1 gene polymorphisms of Gly71Arg and TATA promoter were significant risk factors associated with neonatal hyperbilirubinemia.Material/MethodsThe PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between UGT1A1 polymorphisms and neonatal hyperbilirubinemia. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.ResultsA total of 32 eligible studies and 6520 participants were identified. Among them, 24 studies focused on the association of neonatal hyperbilirubinemia with UGT1A1 Gly71Arg polymorphisms, and a significant difference was found for the comparison of AA vs. AG+GG (OR=3.47, 95% CI=2.29–5.28, P<0.0001). We included 19 studies on the association of neonatal hyperbilirubinemia with UGT1A1 TATA promoter polymorphism, which also found a statistically significant difference between 7/7 and 6/7 + 6/6 (OR=2.24, 95% CI=1.29–3.92, P=0.004).ConclusionsThis meta-analysis demonstrated that UGT1A1 polymorphisms (Gly71Arg and TATA promoter) significantly increase the risk of neonatal hyperbilirubinemia.

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Roles of UGT1A1 Gly71Arg and TATA promoter polymorphisms in neonatal hyperbilirubinemia: A meta-analysis

Wang

Yin

Xue

et al. 2020

Gene

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G71R mutation of the UGT1A1 gene is not associated with neonatal hyperbilirubinemia in India

Cited by 4 publications

References 6 publications

Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults

Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults

Association of Neonatal Hyperbilirubinemia with UGT1A1 Gene Polymorphisms: A Meta-Analysis

Roles of UGT1A1 Gly71Arg and TATA promoter polymorphisms in neonatal hyperbilirubinemia: A meta-analysis

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