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Cited by 3 publications
(4 citation statements)
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“…Interestingly, the genome of a hadal snailfish captured from Yap Trench has more copies of RAD51 than other teleost genomes analyzed, 15 indicating that the enhanced formation of RAD51 filaments mediated by BRCA2 may be essential for hadal adaptation . G2E3 , the expression of which is induced by DNA damage, participates in replication fork recovery by activating checkpoint kinase 1 (CHK1) kinase 79 , 91 , 92 ( Figure 4 A). We identified 20 copies of G2E3 in the YHSC genome, compared with three at most in all other genomes examined ( Figure 4 E).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, the genome of a hadal snailfish captured from Yap Trench has more copies of RAD51 than other teleost genomes analyzed, 15 indicating that the enhanced formation of RAD51 filaments mediated by BRCA2 may be essential for hadal adaptation . G2E3 , the expression of which is induced by DNA damage, participates in replication fork recovery by activating checkpoint kinase 1 (CHK1) kinase 79 , 91 , 92 ( Figure 4 A). We identified 20 copies of G2E3 in the YHSC genome, compared with three at most in all other genomes examined ( Figure 4 E).…”
Section: Resultsmentioning
confidence: 99%
“… 72 , 77 Meanwhile, BRCA2 catalyzes the formation and stabilization of RAD51-ssDNA filaments, which protects nascent DNA from MRE11-mediated nucleolytic degradation. 69 , 78 Then, CHK1 is activated with the help of G2E3, 79 and the replication fork restarts after obstacle removal. 69 , 71 (B) In the translesion synthesis pathway, RAD18 and RAD6 interact with the ssDNA-RPA complex and then ubiquitinate proliferating cell nuclear antigen (PCNA).…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, 5 of these genes accumulated in the G2 phase of the cell cycle. G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) as a nucleo-cytoplasmic shuttling protein was implicated in the DNA damages response and cell cycle regulation [ 35 ], and then attenuated replicative stress [ 36 ]. Previous study also showed that Beet severe curly top virus (BSCYV) can induce RKP (a functional ubiquitin E3 ligase), which is able to interact with cell cycle inhibitor ICK/KRP proteins to regulate the cell cycle [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Expression levels in G2E3 were also observed to increase during early embryogenesis, specifically during central nervous system development. This enzyme is also implicated in cell cycle progression and DNA damage response [85,87,88].…”
Section: G2e3 a Unique Multifunctional Hect E3 Ubiquitin Ligase Withmentioning
confidence: 99%