2014
DOI: 10.4049/jimmunol.1301875
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Abstract: The interleukin-8 (IL-8/CXCL8) receptors, CXCR1 and CXCR2, couple to Gαi to induce leukocyte recruitment and activation at sites of inflammation. We have recently shown that CXCR1 couples predominantly to the G protein-coupled receptor (GPCR) kinase-2 (GRK2) whereas CXCR2 interacts with GRK6 to regulate cellular responses. In addition to GPCRs, GRKs have displayed a more diverse protein/protein interaction in cells. In this study we sought to identify GRK6 binding partner(s) that may influence CXCL8 activities… Show more

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Cited by 23 publications
(27 citation statements)
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“…6C). In agreement with our results, overexpression of AGS3 in RBL-2H3-CXCR2 cells reduced chemokine induced increases in intracellular calcium and an AGS3 knockdown enhanced CXCR2 expression (27). Together, these data suggest that elevated levels of AGS3 in macrophages lowers pAKT levels, which leads to decreased mTOR activity, the translocation of TFEB into the nucleus, and enhanced lysosome biogenesis.…”
Section: Resultssupporting
confidence: 91%
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“…6C). In agreement with our results, overexpression of AGS3 in RBL-2H3-CXCR2 cells reduced chemokine induced increases in intracellular calcium and an AGS3 knockdown enhanced CXCR2 expression (27). Together, these data suggest that elevated levels of AGS3 in macrophages lowers pAKT levels, which leads to decreased mTOR activity, the translocation of TFEB into the nucleus, and enhanced lysosome biogenesis.…”
Section: Resultssupporting
confidence: 91%
“…In contrast, low AGS3 levels likely boost the availability of G i . Similar to our results, the overexpression of AGS3 in RBL-2H3-CXCR2 cells reduced chemokine induced increases in intracellular calcium (27). …”
Section: Discussionsupporting
confidence: 89%
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“…A growing number of cellular and physiologic roles have been ascribed to GPR proteins in systems where signal modulation and adaptation are critical for system responsiveness (Bowers et al, 2004(Bowers et al, , 2008Yao et al, 2005Yao et al, , 2006Blumer et al, 2008;Nadella et al, 2010;Regner et al, 2011;Chauhan et al, 2012;Kwon et al, 2012;Giguère et al, 2013;Kamakura et al, 2013;Branham-O'Connor et al, 2014;Singh et al, 2014). The immune system is certainly an area rich in signaling modulation and adaptation and requires dynamic signal processing and spatially integrated G-protein signaling (Cho and Kehrl, 2009;Kehrl et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…AGS3 is involved in a number of biological functions in addition to asymmetric cell division, including addiction (Bowers et al, 2004(Bowers et al, , 2008Yao et al, 2005Yao et al, , 2006, polycystic kidney disease and response to renal ischemia reperfusion injury (Nadella et al, 2010;Regner et al, 2011;Kwon et al, 2012), cardiovascular regulation (Blumer et al, 2008;Chauhan et al, 2012), lysosomal biogenesis and bacterial infection (Vural et al, 2016), and chemokine signal processing (including leukocyte chemotaxis) (Kamakura et al, 2013;Branham-O'Connor et al, 2014;Singh et al, 2014). The immune system in particular requires dynamic signal processing and spatially integrated G-protein signaling, including the use of accessory proteins (e.g., (Moratz et al, 2000(Moratz et al, , 2004Han et al, 2005Han et al, , 2006Hwang et al, 2013;Boularan and Kehrl, 2014;Branham-O'Connor et al, 2014;Huang et al, 2014;Boularan et al, 2015;Hwang et al, 2015).…”
Section: Introductionmentioning
confidence: 99%