“…AGS3 is involved in a number of biological functions in addition to asymmetric cell division, including addiction (Bowers et al, 2004(Bowers et al, , 2008Yao et al, 2005Yao et al, , 2006, polycystic kidney disease and response to renal ischemia reperfusion injury (Nadella et al, 2010;Regner et al, 2011;Kwon et al, 2012), cardiovascular regulation (Blumer et al, 2008;Chauhan et al, 2012), lysosomal biogenesis and bacterial infection (Vural et al, 2016), and chemokine signal processing (including leukocyte chemotaxis) (Kamakura et al, 2013;Branham-O'Connor et al, 2014;Singh et al, 2014). The immune system in particular requires dynamic signal processing and spatially integrated G-protein signaling, including the use of accessory proteins (e.g., (Moratz et al, 2000(Moratz et al, , 2004Han et al, 2005Han et al, , 2006Hwang et al, 2013;Boularan and Kehrl, 2014;Branham-O'Connor et al, 2014;Huang et al, 2014;Boularan et al, 2015;Hwang et al, 2015).…”