G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis

Shi, Yanan; Liu, Xiaochun; Zhu, Ping; Li, Jianzhen; Sham, Kathy W.Y.; Cheng, Shuk Han; Li, Shuisheng; Zhang, Yong; Cheng, Christopher H.K.; Lin, Haoran

doi:10.1016/j.bbrc.2013.03.130

Cited by 38 publications

(33 citation statements)

References 32 publications

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“…The brain expression of esr2a and esr2b is clearly visible at 36 hpf and increases between 48 and 60 hpf in the forebrain and in the hypothalamus [119]. Whole mount in situ hybridization revealed that gper expression in the brain is detected after 18 hpf and is obvious at 36 hpf in the diencephalon, the midbrain and the midhindbrain boundary [122]. All estrogen receptors are doubtless fully functional at these stages of development as demonstrated by several studies.…”

Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 91%

“…The strong increase in basal AroB expression at 24 hpf relies on estrogen receptors activation because treatment of zebrafish embryos with ICI 182780 strongly reduced the AroB expression rise [119] and it has been shown with the use of morpholino knock-down technology of the three nuclear receptors isoforms that the AroB expression is specifically induced through ERb2 receptors [123]. Knock-down experiments with Gper specific morpholinos induce profound alterations of apoptosis and proliferation that lead to morphological defect of the developing brain [122].…”

Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 99%

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Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Pellegrini

Diotel

Vaillant-Capitaine

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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Estrogens are known as steroid hormones affecting the brain in many different ways and a wealth of data now document effects on neurogenesis. Estrogens are provided by the periphery but can also be locally produced within the brain itself due to local aromatization of circulating androgens. Adult neurogenesis is described in all vertebrate species examined so far, but comparative investigations have brought to light differences between vertebrate groups. In teleost fishes, the neurogenic activity is spectacular and adult stem cells maintain their mitogenic activity in many proliferative areas within the brain. Fish are also quite unique because brain aromatase expression is limited to radial glia cells, the progenitor cells of adult fish brain. The zebrafish has emerged as an interesting vertebrate model to elucidate the cellular and molecular mechanisms of adult neurogenesis, and notably its modulation by steroids. The main objective of this review is to summarize data related to the functional link between estrogens production in the brain and neurogenesis in fish. First, we will demonstrate that the brain of zebrafish is an endogenous source of steroids and is directly targeted by local and/or peripheral steroids. Then, we will present data demonstrating the progenitor nature of radial glial cells in the brain of adult fish. Next, we will emphasize the role of estrogens in constitutive neurogenesis and its potential contribution to the regenerative neurogenesis.Finally, the negative impacts on neurogenesis of synthetic hormones used in contraceptive pills production and released in the aquatic environment will be discussed.

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Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 91%

Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 99%

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Pellegrini

Diotel

Vaillant-Capitaine

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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show abstract

“…This suggests important roles of brain estradiol receptors in both neuroendocrine and neurogenesis functions in the eel. In the zebrafish, nuclear and membrane estrogen receptors have been shown to be involved in neurogenesis (Diotel et al, 2013;Froehlicher et al, 2009;Griffin et al, 2013;Shi et al, 2013). Identification of brain cell types expressing the estrogen receptors in the eel will further clarify this issue.…”

Section: Brain Differential Expression and Regulation Of The Five Estmentioning

confidence: 96%

Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Lafont

Rousseau

Tomkiewicz

et al. 2016

General and Comparative Endocrinology

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“…The onset of menopause is associated with increased obesity, insulin resistance, diabetes and osteoporosis [ Ohlsson and Vandenout, 2009;Shi et al, 2013]. Estrogen action via its receptors acts in distinct but cooperative ways that results in the regulation of glucose and lipid metabolism, adiposity, body fat distribution, and obesity.…”

Section: Energy Homeostasis Metabolic Effects and Bone Remodelingmentioning

confidence: 99%