G-6-PD Deficiency Gene Dynamics in a Brazilian Population

Abstract

SummaryStudies on the glucose-6-phosphate dehydrogenase activity of erythrocytes from 416 males and 820 females are reported. The total number of deficient males (intermediate + complete) varied from 3.9% among the whites (102 persons) to 15.1% among Dark Mulattoes (99 individuals); the incidence in the Negroid sample in general (316 persons) was 12.4%. The data obtained among the women were utilized to study problems of penetrance of the G-6-PDD genes. Results obtained in both sexes were employed to verify, unsuccessfully, possible selection differentials through age analysis and the comparison of the gene incidences of people affected with minor ailments and controls. Problems of gene flow analysis in populations like this one in which the “Negro” and “White” forms of the deficiency are present were stressed.

Genetics, surnames, grandparents' nationalities, and ethnic admixture in Southern Brazil: Do the patterns of variation coincide?

“…The non-Indian populations of the States of Rio Grande do Sul and Santa Catarina have been fairly well studied in the last three decades (Tondo and Salzano, 1962;Tondo et al, 1963;Salzano, 1963;Schwantes et al, 1967;Salzano et al, 1967Salzano et al, , 1968aLewgoy and Salzano, 1968;Hutz et al, 1977;Weimer et al, 1981Weimer et al, , 1987Weimer et al, , 1993Franco et al, 1981Franco et al, , 1982Franco et al, , 1986Silva et al, 1981;Franco and Salzano, 1985;Rieger et al, 1988;Arai et al, 1989;Bortolini et al, 1992Bortolini et al, , 1994Bortolini et al, , 1995Bortolini et al, , 1997aBortolini et al, ,b, 1998Heidrich et al, 1995;Robinson et al, 1998). However, these investigations have not provided a detailed distribution pattern of the polymorphisms investigated, nor a comparison with attributes such as grandparents' nationalities or the individuals' surnames, which could give clues about the history of these groups.…”

Fertility of Abnormal Hemoglobin Carriers in Porto Alegre, Brazil

“…On the other hand, a somewhat larger inbreeding coefficient (0.0038) was found in the couples with abnormal hemoglobin carriers, as compared with their controls (0.0011); but it is felt that the differ ence was not large enough to influence the results to be reported below in a significant way. In order to check for other concomitant variables, tests for the ABO, MN and Rh blood groups, the haptoglobins and glucose-6-phosphatc dehydrogenase (G-6-PD) deficiency were performed with the blood of these individuals according to methods currently in use in our laboratory [10,17,21].…”