volume 27, issue 2, P243-252 2011
DOI: 10.3233/jad-2011-110353
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Kai Yang, Jillian Belrose, Catherine H. Trepanier, Gang Lei, Michael F. Jackson, John F. MacDonald

Abstract: Alzheimer's disease (AD) is the most common form of dementia characterized by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles. The mechanisms leading to AD are not completely understood; however, recent evidence suggests that alterations in Fyn, a Src family kinase, might contribute to AD pathogenesis. A number of studies have demonstrated that Fyn is involved in synaptic plasticity, a cellular mechanism for learning and memory. In addition, Fyn plays a role in the regulation of Aβ productio…

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