volume 39, issue 1, P54-64 2011
DOI: 10.1016/j.jcms.2010.03.016
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J. Fischer, A. Kolk, St. Wolfart, C. Pautke, P.H. Warnke, C. Plank, R. Smeets

Abstract: The most promising attempts to achieve bone regeneration artificially are based on the application of mediators such as bone morphogenetic proteins (BMPs) directly to the deficient tissue site. BMPs, as promoters of the regenerative process, have the ability to induce de novo bone formation in various tissues, and many animal models have demonstrated their high potential for ectopic and orthotopic bone formation. However, the biological activity of the soluble factors that promote bone formation in vivo is lim…

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