Further subclassification of ATP receptors based on agonist studies

Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

“…In this report we describe the cloning and expression of a cDNA encoding a novel GCR that binds ATP. This receptor displays a P,, purinoceptor pharmacology distinct from the classical [2,4] type. On the basis of this pharmacological evidence, we designate this novel subtype as a PzY, purinoceptor.…”

“…At least five subtypes of P, purinoceptors have been proposed pharmacologically [2,4], with P,, and PzY purinoceptors the best described. However, none has as yet been characterised at the molecular level.…”

“…However, none has as yet been characterised at the molecular level. The P,, purinoceptor has the properties of an ATP-gated cation channel [5], whereas other P, purinoceptor subtypes appear to be members of the GCR superfamily [4,6].…”

Purinergic signalling-evoked intracellular Ca2+ concentration changes in the regulation of chondrogenesis and skeletal muscle formation

“…Identification of the members of the P2 receptor family started with the description of their distinct and sometimes contradictory cellular effects [11]. The original notion in 1985 that P2X and P2Y receptors should be distinguished was based on pharmacological data [12].…”

“…Today seven members of the ionotropic (P2X [1][2][3][4][5][6][7] ) and eight members of the metabotropic (P2Y 1,2,4,6,[11][12][13][14] ) purinergic receptors have been cloned and identified in mammals [13,14]. In 6 case of P2X receptors the seven members of the subfamily refer to seven distinct subunits as discussed below.…”