Further Studies on the Mechanism of Adhesive Tape Dermatitis

Skin Irritation in Transdermal Drug Delivery Systems: A Strategy for its Reduction

“…Other factors include bacterial infection produced by sweating (18,19) and chemical or allergic irritation produced by the adhesive itself (20,21). However the difference in physical irritation could be excluded in this study because the same backing layer and basic adhesive composition were used in the devices.…”

Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application

“…Traumatic reactions to these systems are mainly induced by maceration of the occluded skin. The combination of sweat accumulation and a local rise in temperature due to occlusion will also create an ideal climate for the growth of bacteria and/or yeasts, which possibly also contribute to traumatic reactions under long-term transdermal therapeutic systems (Peck, Michelfelder & Palitz, 1951;Marples & Kligman, 1969). Long-term occlusion ofthe skin with a transdermal therapeutic system inevitably causes accumulation of sweat at the skin surface in absence of evaporation.…”