Further Gonioscopic Studies on the Canal of Schlemm

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

“…Changes in cellularity and extracellular matrix elements are associated with the glaucoma process in both animal models and in glaucoma patients. 44 – 50 Pulsatile aqueous flow progressively decreases and is eventually lost as the glaucoma process worsens. 44 – 46 In glaucoma patients, miotics transiently restore pulsatile aqueous flow into episcleral veins followed by a drop in IOP that persists throughout the duration of action of the drug.…”

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

“…Changes in cellularity and extracellular matrix elements are associated with the glaucoma process in both animal models and in glaucoma patients. 44 – 50 Pulsatile aqueous flow progressively decreases and is eventually lost as the glaucoma process worsens. 44 – 46 In glaucoma patients, miotics transiently restore pulsatile aqueous flow into episcleral veins followed by a drop in IOP that persists throughout the duration of action of the drug.…”

Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

“…[34][35][36][37][38] Physiologic positions, such as those commonly occurring in physical fitness activities, can cause pressure reversal with pressure in SC being higher than IOP. 39 During the physical activities involving body inversion, episcleral venous pressure rapidly rises.…”

“…In the later stages of the disease, some regions of the canal no longer fill with blood, while in far advanced disease, no SC blood filling is observed. [34][35][36][37][38] Altered blood reflux into SC represents the only directly observable abnormality of the TM and SC regions in glaucoma.…”

Aqueous outflow regulation – 21st century concepts

“…In advanced glaucoma, blood fails to reflux into SC, even with very aggressive measures to reverse pressure gradients ( Kronfeld, 1949 ). The lack of ability to reflux blood into SC as the glaucoma process advances provides a means to separate normal subjects from ocular hypertensives and those with glaucoma ( Schirmer, 1969 , 1971 ).…”

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

“…Changes in cellularity and extracellular matrix elements are associated with the glaucoma process in both animal models and in glaucoma patients. 44 – 50 Pulsatile aqueous flow progressively decreases and is eventually lost as the glaucoma process worsens. 44 – 46 In glaucoma patients, miotics transiently restore pulsatile aqueous flow into episcleral veins followed by a drop in IOP that persists throughout the duration of action of the drug.…”

Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

“…[34][35][36][37][38] Physiologic positions, such as those commonly occurring in physical fitness activities, can cause pressure reversal with pressure in SC being higher than IOP. 39 During the physical activities involving body inversion, episcleral venous pressure rapidly rises.…”

“…In the later stages of the disease, some regions of the canal no longer fill with blood, while in far advanced disease, no SC blood filling is observed. [34][35][36][37][38] Altered blood reflux into SC represents the only directly observable abnormality of the TM and SC regions in glaucoma.…”

Aqueous outflow regulation – 21st century concepts

“…In advanced glaucoma, blood fails to reflux into SC, even with very aggressive measures to reverse pressure gradients ( Kronfeld, 1949 ). The lack of ability to reflux blood into SC as the glaucoma process advances provides a means to separate normal subjects from ocular hypertensives and those with glaucoma ( Schirmer, 1969 , 1971 ).…”

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

“…Changes in cellularity and extracellular matrix elements are associated with the glaucoma process in both animal models and in glaucoma patients. 44 – 50 Pulsatile aqueous flow progressively decreases and is eventually lost as the glaucoma process worsens. 44 – 46 In glaucoma patients, miotics transiently restore pulsatile aqueous flow into episcleral veins followed by a drop in IOP that persists throughout the duration of action of the drug.…”

Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

“…[34][35][36][37][38] Physiologic positions, such as those commonly occurring in physical fitness activities, can cause pressure reversal with pressure in SC being higher than IOP. 39 During the physical activities involving body inversion, episcleral venous pressure rapidly rises.…”

“…In the later stages of the disease, some regions of the canal no longer fill with blood, while in far advanced disease, no SC blood filling is observed. [34][35][36][37][38] Altered blood reflux into SC represents the only directly observable abnormality of the TM and SC regions in glaucoma.…”

Aqueous outflow regulation – 21st century concepts

“…In advanced glaucoma, blood fails to reflux into SC, even with very aggressive measures to reverse pressure gradients ( Kronfeld, 1949 ). The lack of ability to reflux blood into SC as the glaucoma process advances provides a means to separate normal subjects from ocular hypertensives and those with glaucoma ( Schirmer, 1969 , 1971 ).…”