Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale

(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved

“…Watercress as a medicinal plant has its origins in the ancient and traditional medicines of Iran, where it is used to treat pathologies such as renal colic, hypertension and hyperglycemia. 1 In the literature, the different biological activities of this plant extract are described, such as cardioprotective, 2,3 hypolipidemic, 4 anticancer, [5][6][7][8][9] antioxidant, 2,10-15 antiinflammatory, 10,12,[15][16][17] antidiabetic, 18 antibacterial, 19,20 antiallergic, 21 and antipsoriatic activities, 22 as well as its effects on the reproductive system. 23 In addition to its use as a medicinal substance, watercress has shown interesting activities in the field of cosmetics due to its anti-ageing, skin-brightening and anti-acne effects, in phytoremediation and at a nutritional level, because it is currently becoming one of the most interesting vegetables in healthy diet and in modern cuisine.…”

“…Watercress as a medicinal plant has its origins in the ancient and traditional medicines of Iran, where it is used to treat pathologies such as renal colic, hypertension and hyperglycemia. 1 In the literature, the different biological activities of this plant extract are described, such as cardioprotective, 2,3 hypolipidemic, 4 anticancer, 5–9 antioxidant, 2,10–15 anti-inflammatory, 10,12,15–17 antidiabetic, 18 antibacterial, 19,20 antiallergic, 21 and antipsoriatic activities, 22 as well as its effects on the reproductive system. 23…”

“…33,41 While several studies have described the anti-inflammatory and antioxidant effects of N. officinale, there is limited information on the pharmacological activity of (R)-8-OITC. [15][16][17] Considering that most probably all natural methylsulfinyl analogues exist as a single enantiomer with an R S absolute configuration, 42 we decided to focus on the study of the biological activity of (R)-8-OITC related to its anti-inflammatory effect.…”