Further Evidence of a Plasma Factor in Schizophrenia

Effect of a Protein Factor Isolated from Schizophrenic Blood on Permeability

“…Freshly drawn chicken erythrocytes were added to Krebs-Ringer solution and incubated with plasma from control and schizophrenic subjects by the method described elsewhere [1,2]. For each subject three flasks were prepared.…”

“…The third flask was incubated at 0°C for one hour, the cells and the media separated and lactate and pyruvate determined on each portion. Details of the methodology have been described elsewhere [1,2].…”

“…A number of previous reports [1,2] from this laboratory have pre sented data showing that ratios of lactate to pyruvate remaining in a chicken erythrocyte mixture that has been incubated with plasma from schizophrenic patients are significantly higher than those from the post-incubation mixture of chicken erythrocytes and plasma from control subjects. This difference in L/P ratios, as measured in the two groups of incubation mixtures, is apparently caused by a substance in plasma that is probably a protein, and is present in excessive amounts in the plasma of the schizophrenic patients [3,4].…”

A Critical Review of Endogenous Psychotoxins as a Cause of Schizophrenia

“…In his study of nitrogen metabolism in periodic catatonia Gjessing (54) sug gested the possibility of a relationship between intermediary protein metabolism and schizophrenia. Many groups have re ported the existence of unusual plasma proteins in schizophrenics (42,44,57,78,108); however, as Kety pointed out (74), many of these studies have failed to con-trol dietary and other important factors in the patients.…”

Ενζυμικη Δραστικοτης Της Γλυκοζο - 6 -Φωσφορικης Δευδρογενασης Της Γ - Γλουταμυλ - Τρανσπεπτιδασης Καιτης Λυσοζυμης Εις Την Σχιζοφρενιαν

“…Τό ένζυμον παίζει πρωταρχικον ρόλον είς τον μεταβολισμον του λευκοκυττάρου 19 , είναι δε ούτος συνηρτημένος με την έπιτέλεσιν τών φυσιολογικών του λειτουργιών. Είς άνεπάρκειαν της G-6-PD ή όποια άφορα και είς άλλους, έκτος του ερυθροκυττάρου ιστούς, λαμβάνει χώραν ανώμαλος χρησιμοποίησις της γλυκόζης 20 , τοιαύτη δέ έχει άποδειχθή νά συμβαίνη και είς την σχιζοφρενίαν 21 , 22 , 23 . Ή γ-GT έμελετήθη είς τα λευκά αιμοσφαίρια και τον όρόν.…”