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“…Furoxan-or nitroglycerine-containing imoproxyfan 186,187) analogs have been reported. [188][189][190] Peripherally acting hybrid structures are realised by combining histamine H 1 with H 3 pharmacophores to treat nasal congestion in allergic rhinitis. Combinations with classical H 1 antihistamines have already been reported in the field of imidazole-containing ligands.…”
Section: )mentioning
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“…Furoxan-or nitroglycerine-containing imoproxyfan 186,187) analogs have been reported. [188][189][190] Peripherally acting hybrid structures are realised by combining histamine H 1 with H 3 pharmacophores to treat nasal congestion in allergic rhinitis. Combinations with classical H 1 antihistamines have already been reported in the field of imidazole-containing ligands.…”
Section: )mentioning
“…Gasco and co-workers have studied furoxan and related analogues for many years and have published pioneering work towards their syntheses 1522. The key step typically involves treatment of the requisite cinnamyl alcohol 10 with sodium nitrate and acetic acid at room temperature to form the corresponding 4-phenyl-3-furoxanmethanol derivative 11 .…”
mentioning
“…Derivative 44 (Figure 12 ) showed additional NO-dependent muscle relaxation (Bertinaria, 2003 ; Bertinaria et al, 2003 ). Another potent compound 45 is derived from Imoproxifan 46 (Figure 12 ) by replacing the oxime moiety with a five-membered NO-donor furoxan ring (Tosco et al, 2005 ). As a further development, a new class of NO-donor H 3 R antagonists with non-basic (thio)ether linker and furoxan ( 47 ) or nitrooxy ( 48 ) NO-donor moieties is introduced (Figure 12 ).…”
Section: H 3 R and No-releasing Moleculesmentioning