Furosemide for prevention of morbidity in indomethacin-treated infants with patent ductus arteriosus

Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review

“… 24 , 25 We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects. 15 Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects. Thus, further research on this topic is warranted.…”

“…Ibuprofen is typically used as an alternative to indomethacin for PDA treatment as it exhibits equal efficacy and few adverse effects 24,25 . We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects 15 . Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects.…”

“…14 However, this RCT was a new trial that was not included in a previous systematic review on this topic. 14,15 Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence. Second, we excluded articles written in languages other than English or Japanese.…”

“…Moreover, one RCT accounted for a large proportion of the results of this study because this RCT included a large number of patients 14 . However, this RCT was a new trial that was not included in a previous systematic review on this topic 14,15 . Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence.…”

“…Second, we excluded articles written in languages other than English or Japanese. The trials that were excluded due to this restriction had a small sample size and had results that were similar to those of other included studies 15,18 . We therefore considered that our results were not influenced by the exclusion of these studies.…”

Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review

“… 24 , 25 We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects. 15 Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects. Thus, further research on this topic is warranted.…”

“…Ibuprofen is typically used as an alternative to indomethacin for PDA treatment as it exhibits equal efficacy and few adverse effects 24,25 . We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects 15 . Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects.…”

“…14 However, this RCT was a new trial that was not included in a previous systematic review on this topic. 14,15 Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence. Second, we excluded articles written in languages other than English or Japanese.…”

“…Moreover, one RCT accounted for a large proportion of the results of this study because this RCT included a large number of patients 14 . However, this RCT was a new trial that was not included in a previous systematic review on this topic 14,15 . Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence.…”

“…Second, we excluded articles written in languages other than English or Japanese. The trials that were excluded due to this restriction had a small sample size and had results that were similar to those of other included studies 15,18 . We therefore considered that our results were not influenced by the exclusion of these studies.…”

Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review

“… 24 , 25 We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects. 15 Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects. Thus, further research on this topic is warranted.…”

“…Ibuprofen is typically used as an alternative to indomethacin for PDA treatment as it exhibits equal efficacy and few adverse effects 24,25 . We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects 15 . Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects.…”

“…14 However, this RCT was a new trial that was not included in a previous systematic review on this topic. 14,15 Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence. Second, we excluded articles written in languages other than English or Japanese.…”

“…Moreover, one RCT accounted for a large proportion of the results of this study because this RCT included a large number of patients 14 . However, this RCT was a new trial that was not included in a previous systematic review on this topic 14,15 . Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence.…”

“…Second, we excluded articles written in languages other than English or Japanese. The trials that were excluded due to this restriction had a small sample size and had results that were similar to those of other included studies 15,18 . We therefore considered that our results were not influenced by the exclusion of these studies.…”

Furosemide for patent ductus arteriosus during cyclooxygenase inhibitor therapy: A systematic review

“… 24 , 25 We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects. 15 Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects. Thus, further research on this topic is warranted.…”

“…Ibuprofen is typically used as an alternative to indomethacin for PDA treatment as it exhibits equal efficacy and few adverse effects 24,25 . We investigated the effects of furosemide during ibuprofen therapy because the previous systematic review did not evaluate these effects 15 . Although we expected to find new clinical trials investigating furosemide during ibuprofen therapy, we definitively confirm that no currently published studies have investigated these effects.…”

“…14 However, this RCT was a new trial that was not included in a previous systematic review on this topic. 14,15 Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence. Second, we excluded articles written in languages other than English or Japanese.…”

“…Moreover, one RCT accounted for a large proportion of the results of this study because this RCT included a large number of patients 14 . However, this RCT was a new trial that was not included in a previous systematic review on this topic 14,15 . Although RCTs with larger sample sizes are needed to confirm our findings, the results of this study are important as they highlight the paucity of existing evidence.…”

“…Second, we excluded articles written in languages other than English or Japanese. The trials that were excluded due to this restriction had a small sample size and had results that were similar to those of other included studies 15,18 . We therefore considered that our results were not influenced by the exclusion of these studies.…”