Furanocoumarins from the root ofAngelica dahurica

Abstract

Five furanocoumarins including a new one were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were determined to be isoimperatorin (1), oxypeucedanin hydrate-3"-butyl ether (2), imperatorin (3), knidilin (4), and oxypeucedanin hydrate (5). This represents the first study in which the compound 2 has been isolated and identified. The long-range coupling (5J) in the 1H-NMR spectrum observed in the linear furanocoumarin skeleton was also investigated in detail.

Imperatorin Is a Mechanism-Based Inactivator of CYP2B6

“…Imperatorin (IMP), a linear furanocoumarin compound, is the major active ingredient in many common umbelliferous herbs used as traditional Chinese medicines, such as Cnidium monniericuss and Angelica dahurica (Baek et al, 2000;Lia and Chen, 2004). The IMPcontaining herbs are widely used in China for the treatment of osteoporosis and relief of swelling and pain (Zhang et al, 2003).…”

Agents Protecting against Sepsis from the Roots of Angelica dahurica

“…Their structures were identified by comparison of optical rotations, 1 H-and 13 C-NMR, DEPT, and MS data with the reported ones of the corresponding compounds. 13,[17][18][19][20][21] Among the purified compounds, 3 showed the strongest protective effect against lethality induced by LPS/D-GalN ( Table 2). Pretreatment of mice with 3 at doses of 3, 10, and 30 mg/kg increased survival rates to 40%, 80%, and 100%, respectively, compared with 20% in the control experiment, while pretreatment with dexamethasone as a positive control at doses of 3, 10, and 30 mg/kg increased survival rates to 60%, 100%, and 100%, respectively.…”

“…1 (543 mg) was recrystallized from hexaneEtOAc (6 : 4) to give isoimperatorin (1, 380 mg, pale yellow crystal, mp 104-106°C). 17) Fr. 4 (600 mg), Fr.…”

“…10 (1.97 g), and Fr. 11 (3 g 17,20,21) respectively. The structures of the four compounds are shown in Fig.…”

Two New Furanocoumarins from the Roots of Angelica dahurica

“…3 Some coumarins and furanocoumarins have been reported from this plant. [3][4][5][6][7][8][9] Two new furanocoumarins (1 and 2) were isolated from the n-BuOH extract of the roots of A. dahurica. The structure elucidation and biological activity of the compounds are described herein.…”