Funktionale molekulare dünne Filme: topologische Template für die chemoselektive Bindung antigener Peptide an selbstorganisierte Monoschichten

The structural prototype of a new generation of regioselectively addressable functionalized templates (RAFTs) for use in protein de novo design has been synthesized and crystallized. The structure of the aromatically substituted cyclodecapeptide was determined by X-ray diffraction; it consists of an antiparallel beta sheet spanned by heterochirally induced type IIprime prime or minute beta turns, similar to that observed in gramicidin S. The three-dimensional structure of the artificial template was also examined by an NMR spectroscopic analysis in solution and shown to be compatible with a beta-sheet plane suitable for accommodating secondary functional peptide fragments for the synthesis of template-assembled synthetic proteins (TASPs).

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Crystal Structure of a Synthetic Cyclodecapeptide for Template-Assembled Synthetic Protein Design

Peluso

Rückle

Lehmann

et al. 2001

ChemBioChem

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Synthetic Peptide Templates for Molecular Recognition: Recent Advances and Applications

et al. 2006

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The creation of molecular systems that can mimic some of the properties of natural macromolecules is one of the major endeavors in contemporary protein chemistry. However, the construction of artificial proteins with predetermined structure and function is difficult on account of complex folding pathways. The use of topological peptide templates has been suggested to induce and stabilize defined secondary and tertiary structures. This is because the recent advances in the chemistry of coupling reagents, protecting groups, and solid-phase synthesis have made the chemical synthesis of peptides with conformationally controlled and complex structures feasible. Besides their use as structure-inducing devices, these peptide templates can also be utilized to construct novel structures with tailor-made functions. Herein, we present recent advances in the field of peptide-template-based approaches with particular emphasis on the demonstrated utility of this approach in molecular recognition, along with related applications.

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Directed Organic Grafting on Locally Doped Silicon Substrates

Charlier

Baraton

Bureau³

et al. 2005

ChemPhysChem

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Funktionale molekulare dünne Filme: topologische Template für die chemoselektive Bindung antigener Peptide an selbstorganisierte Monoschichten

Cited by 8 publications

References 38 publications

Crystal Structure of a Synthetic Cyclodecapeptide for Template-Assembled Synthetic Protein Design

Crystal Structure of a Synthetic Cyclodecapeptide for Template-Assembled Synthetic Protein Design

Synthetic Peptide Templates for Molecular Recognition: Recent Advances and Applications

Directed Organic Grafting on Locally Doped Silicon Substrates

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