Fungicidal and spectral studies of some triphenyltin compounds

Abstract

In the interest of developing a more effective fungicide to combat Dutch elm disease, our laboratories have synthesized several triphenyltin carboxylates and some 1:1 addition compounds of triphenyltin chloride using 2,3-disubstituted thiazolidin-4-ones as the ligand and screened them in vitro against Ceratocystis ulmi, the causative agent of Dutch elm disease, using a shake culture method. Elemental analyses and spectroscopic data indicate that the structures of the carboxylates in the solid state are monomeric with a tetrahedral tin atom with the exception of the furan-2-carboxylic acid derivative, which was found to be polymeric. The triphenyltin chloride adducts are trigonal-bipyramidal with the three phenyl groups in the equatorial plane. Far-infrared data indicate that the three phenyl groups are not co-planar. Screening results for both series of organotins indicate that these two classes of compounds are effective inhibitors of Ceratocystis ulmi, with the adducts having a higher activity. The furan-2-carboxylic acid derivative has a markedly decreased activity compared with the other carboxylates and this is attributed to its polymeric structure.

Biological activity studies on organotin(IV)+ complexes and parent compounds

“…The Ph 3 SnCl adducts are TBP (|D exp | = 2.97-3.08 mm s À1 ) with the three {Ph} groups in a non-coplanar eq plate. These complexes are effective inhibitors of C. ulmi [52].…”

Synthesis, Spectral Characterization and Solubility Studies Of Some Organotin Carboxylates

“…In recent times, pharmaceutical properties of organotin carboxylates have been investigated, with particular reference to their antitumour properties [7]. Biocidal uses of organotin carboxylates have continued to attract attention [9], [10]. There is also interest in the structural chemistry of the compounds [11], [12], [13].…”

Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

“…The current research dealing with metal complexes of heteronuclear Schiff bases has expanded enormously and includes diversified subjects comprising their various aspects in biocoordination and bioinorganic chemistry. It is known that the presence of metal ions bonded to biologically active compounds may enhance their activity [13–16]. Heteronuclear Schiff base complexes have found applications as magnetic materials, catalysts and in the field of bioengineering [17, 18].…”