Fungi in Deep‐Sea Environments and Metagenomics

Mahé, Stéphane; Rédou, Vanessa; Calvez, Thomas Le; Vandenkoornhuyse, Philippe; Burgaud, Gaëtan

doi:10.1002/9781118735893.ch15

Cited by 14 publications

(9 citation statements)

References 137 publications

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“…Deep-sea fungi are the fungi that inhabit the sea and its sediment at a depth of over 1000 m below the surface [ 2 ]. Although the conditions in deep-sea environments are extreme and can be characterized by the absence of sunlight irradiation, predominantly low temperature, high hydrostatic pressure, and oligotrophy, it has been reported that fungi are abundant and diverse in these environments [ 3 , 4 , 5 ]. According to literature surveys, the first documented deep-sea fungi were isolated from the Atlantic Ocean at a depth of 4450 m approximately 50 years ago [ 6 ]; however, it was not until 2006 that the first bioactive metabolite of the deep-sea fungus Chromocleista sp.…”

Section: Introductionmentioning

confidence: 99%

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

2015

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Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

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Section: Introductionmentioning

confidence: 99%

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

2015

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“…Deep-sea fungi inhabit at depths of thousand meters or below the surface (Swathi et al, 2013 ) where the sea environments are extreme; which are typically characterized by the absence of sunlight irradiation, predominantly low temperature, high hydrostatic pressure, and oligotrophy. Many reports indicate abundance and diversity of fungi in these environments (Hua et al, 2011 ; Mahé et al, 2013 ). Here, we present an account of metabolites reported from the deep-sea fungi during 2012–2016 that have displayed anticancer activities in various cell lines.…”

Section: Metabolites Isolated From Deep-sea Sediment Fungimentioning

confidence: 99%

Marine Fungi: A Source of Potential Anticancer Compounds

2018

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Metabolites from marine fungi have hogged the limelight in drug discovery because of their promise as therapeutic agents. A number of metabolites related to marine fungi have been discovered from various sources which are known to possess a range of activities as antibacterial, antiviral and anticancer agents. Although, over a thousand marine fungi based metabolites have already been reported, none of them have reached the market yet which could partly be related to non-comprehensive screening approaches and lack of sustained lead optimization. The origin of these marine fungal metabolites is varied as their habitats have been reported from various sources such as sponge, algae, mangrove derived fungi, and fungi from bottom sediments. The importance of these natural compounds is based on their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them. This review covers the majority of anticancer compounds isolated from marine fungi during 2012-2016 against specific cancer cell lines.

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“…Thanks to their unique adaptive capabilities, marine fungi are able to colonize different marine habitats, even the most extreme ones, including deep-sea environments. Although several studies have reported that fungi are abundant and diverse in these habitats [ 40 ], it is anticipated that many remain to be discovered. Access to the actual fungal biodiversity present in the deep-sea could lead to the discovery of new bioactive compounds useful for drug discovery [ 41 ].…”

Section: Antimicrobial Compounds From Marine Microorganismsmentioning

confidence: 99%

Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

et al. 2018

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The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.

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Fungi in Deep‐Sea Environments and Metagenomics

Cited by 14 publications

References 137 publications

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Marine Fungi: A Source of Potential Anticancer Compounds

Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

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