Fungal endophytes: an untapped source of biocatalysts

Suryanarayanan, T. S.; Thirunavukkarasu, N.; Govindarajulu, M.B.; Gopalan, Venkat

doi:10.1007/s13225-012-0168-7

Cited by 134 publications

(67 citation statements)

References 99 publications

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“…Endophytic fungi of plants are a novel source of several enzymes including biomass degrading and pharmaceutical enzymes (Suryanarayanan et al 2012). Many of these fungi produce novel chitinases and chitosanses (Govinda Rajulu et al 2011), proteases (Thirunavukkarasu et al 2017), cellulase, laccase, lipase and pectinase (Govinda Rajulu et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Endolichenic fungi: the lesser known fungal associates of lichens

Suryanarayanan

Thirunavukkarasu

2017

Mycology

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Lichens are the result of a stable mutualism between a fungal and a photosynthesising partner (alga or cyanobacterium). In addition to the fungal partner in this mutualism, lichens are associated with endolichenic fungi which reside inside their thalli. The endolichenic fungi appear to have evolved with the lichen and many of them are a source of novel metabolites vested with unique bioactivities. There is very little information on the biology of endolichenic fungi and their interactions with the other components of a lichen microbiome. There is an urgent need to understand these aspects of endolichenic fungi such that their ecology and economic potential are known more completely. The current knowledge on endolichenic fungi is reviewed here.

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Section: Introductionmentioning

confidence: 99%

Endolichenic fungi: the lesser known fungal associates of lichens

Suryanarayanan

Thirunavukkarasu

2017

Mycology

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“…They are surrounded by plant molecules, among which phenolic and other aromatic substances are especially common. The adaptation to this chemically unique habitat makes these organisms a rich potential source of biocatalysts (Suryanarayanan et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Gonda

Kiss‐Szikszai

Szűcs

et al. 2016

International Biodeterioration & Biodegradation

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In the current study, decomposition of diclofenac, diflunisal, ibuprofen, mefenamic acid and piroxicam was tested using nine identified strains of endophytic and epiphytic fungi (from Ascomycota) adapted to natural products resembling the pharmaceuticals. The strains were isolated from a medicinal plant, Plantago lanceolata leaves. Metabolites were tentatively identified by liquid chromatography -tandem mass spectrometry ).Eighteen of the 45 combinations resulted in significant decrease of the concentration of the NSAIDs in model solutions. The most active strains were Aspergillus nidulans and Bipolaris tetramera, while Epicoccum nigrum and Aspergillus niger showed somewhat less potency. Piroxicam and diclofenac were most resistant to biotransformation, while ibuprofen and mefenamic acid were efficiently metabolized by most strains. Ten metabolites could be tentatively identified, includinghydroxy-metabolites of all tested NSAIDs, and a dihydroxy-metabolite of piroxicam. This biotransformation is likely to modify the toxicity and bioaccumulation potential of these pharmaceuticals.The results highlight the applicability of polyphenol-rich dried medicinal plant materials as an excellent source of fungi with high biotransforming potential. The results also suggest more in-depth testing of these fungi for biodegradation processes.

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“…VINSTROM's global research collaborations have uncovered the biotechnological potential of some of these cultures. Endophytic fungi elaborate anticancer metabolites and plant-growth regulators 12 , antimalarial metabolites 13 , antialgal, antifungal, antibacterial and insecticidal metabolites, and novel enzymes for an array of industries [14][15][16][17][18][19] . If VINSTROM, a small laboratory with minimum resources and a singular focus on one ecological group of fungi (endophytes), could identify several fungal candidates with potentially exploitable traits, a more concerted nationwide effort could be expected to identify unprecedented numbers of fungi with desirable characteristics.…”

Section: Why Study Fungi?mentioning

confidence: 99%