Fungal causes of otitis externa and tympanostomy tube otorrhea

Martin, Timothy J.; Kerschner, Joseph E.; Flanary, Valerie A.

doi:10.1016/j.ijporl.2005.04.012

Cited by 74 publications

(73 citation statements)

References 19 publications

(35 reference statements)

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“…During a 1-year study in Spain, (170). Development of fungal otitis in children was significantly associated with prior oral and ototopical antibacterial agents, with the greatest increase seen after the widespread use of ofloxacin in the clinic.…”

Section: Otomycosismentioning

confidence: 99%

“…However, a correlation between fungal infection and chronic inflammation of the ear has been made, as inflammation, such as erythema, edema, and desquamation of meatal epithelial tissues, resolved in all patients treated with topical antimycotic regimens (279). Aggressive use of antibacterial agents, such as topical quinolone antibiotics, within the ear may be a factor in the occurrence of fungal ear infections (170,250). Successful treatment for mycosis of the auditory canal has included intense debridement and cleansing in combination with topical clotrimazole for a period of 7 to 14 days, although tympanic membrane infections require up to 4 weeks of treatment (279).…”

Section: Otomycosismentioning

confidence: 99%

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Candida parapsilosis, an Emerging Fungal Pathogen

2008

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SUMMARY Candida parapsilosis is an emerging major human pathogen that has dramatically increased in significance and prevalence over the past 2 decades, such that C. parapsilosis is now one of the leading causes of invasive candidal disease. Individuals at the highest risk for severe infection include neonates and patients in intensive care units. C. parapsilosis infections are especially associated with hyperalimentation solutions, prosthetic devices, and indwelling catheters, as well as the nosocomial spread of disease through the hands of health care workers. Factors involved in disease pathogenesis include the secretion of hydrolytic enzymes, adhesion to prosthetics, and biofilm formation. New molecular genetic tools are providing additional and much-needed information regarding C. parapsilosis virulence. The emerging information will provide a deeper understanding of C. parapsilosis pathogenesis and facilitate the development of new therapeutic approaches for treating C. parapsilosis infections.

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Section: Otomycosismentioning

confidence: 99%

Section: Otomycosismentioning

confidence: 99%

Candida parapsilosis, an Emerging Fungal Pathogen

2008

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“…1 A subtype of chronic OE is reported in 6-40% of patients, following insertion of a pressure equalisation tube that leads to middle-ear drainage, purulent or not, causing canal maceration. 13,[16][17][18] …”

Section: Pathophysiologymentioning

confidence: 99%

“…4,8,9,19,24 The ototopical should include an active antimicrobial agent, not just an inhibitor such as acetic acid. [2][3][4]8,16,[19][20][21][22] There are no randomised controlled Other topicals range from aminoglycosides (e.g. neomycin and gentamicin) to fluoroquinolones with or without a concomitant steroid.…”

Section: Treatmentmentioning

confidence: 99%

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Otitis externa: review and clinical update

Osguthorpe

2011

South African Family Practice

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Otitis externa can take an acute or a chronic form, with the acute form affecting four in 1 000 persons annually and the chronic form affecting 3-5% of the population. Acute disease commonly results from bacterial (90% of cases) or fungal (10% of cases) overgrowth in an ear canal subjected to excess moisture, or to local trauma. Chronic disease often is part of a more generalised dermatologic or allergic problem. Symptoms of early acute and most chronic disease include pruritus and local discomfort. If left untreated, acute disease can be followed by canal oedema, discharge, and pain, and eventually by extra-canal manifestations. Topical application of an acidifying solution is usually adequate in treating early disease. An antimicrobial containing ototopical is the preferred treatment for later-stage acute disease, and oral antibiotic therapy is reserved for advanced disease or those who are immunocompromised. Preventative measures reduce recurrences, and typically involve minimising ear canal moisture, trauma, or exposure to materials that incite local irritation or contact dermatitis.

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Dermatoses of the External Ear

Kennedy,

Sharma

2024

Rook's Textbook of Dermatology

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The external ear comprises the pinna (auricle), the external auditory canal and the outer surface of the tympanic membrane. Numerous disorders can affect the ear, from childhood to old age. Ear malformations can arise as developmental abnormalities. Traumatic conditions include contusion, haematoma, split earlobes, pseudocyst, keloid and chondrodermatitis. Infections, including viral, bacterial and fungal, may manifest as acute or chronic otitis externa. Ear signs can be a manifestation of an underlying systemic disorder, such as autoimmune and inflammatory disease. Common cancers affecting the ear include basal cell carcinoma and squamous cell carcinoma, the latter carrying a risk of direct and metastatic spread.

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Fungal causes of otitis externa and tympanostomy tube otorrhea

Cited by 74 publications

References 19 publications

Candida parapsilosis, an Emerging Fungal Pathogen

Candida parapsilosis, an Emerging Fungal Pathogen

Otitis externa: review and clinical update

Dermatoses of the External Ear

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