Fungal Arthritis and Osteomyelitis

Kohli, Rakhi; Hadley, Susan

doi:10.1016/j.idc.2005.08.004

Cited by 89 publications

(71 citation statements)

References 66 publications

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“…IA is a major infectious complication in immunocompromised patients (Kohli & Hadley, 2005). Infection is most commonly acquired through inhalation of Aspergillus spores.…”

Section: Discussionmentioning

confidence: 99%

“…Infection is most commonly acquired through inhalation of Aspergillus spores. Dissemination from a primary pulmonary focus can occur through haematogenous spread (Kohli & Hadley, 2005;Gunsilius et al, 1999). Bone infections in patients with IA are rare (Denning, 1998); in a review of the literature, only 38 (1.8 %) of 2121 cases of IA had bone involvement (Denning & Stevens, 1990).…”

Section: Discussionmentioning

confidence: 99%

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Angio-oedema as an unusual tolerable side effect of voriconazole therapy

Gençer

Özer

DEMİRHAN

et al. 2008

Journal of Medical Microbiology

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Voriconazole (VRC) has not previously been reported to cause angio-oedema. Here, we report a case of angio-oedema associated with VRC therapy. A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy. This condition rapidly diminished after administration of intravenous antihistaminics and did not necessitate cessation of VRC treatment. The treatment was continued for 6 months without recurrence of the symptoms. After 18 months, the patient was in good health. To our knowledge, this is the first report of an angio-oedema associated with VRC.

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“…IA is a major infectious complication in immunocompromised patients (Kohli & Hadley, 2005). Infection is most commonly acquired through inhalation of Aspergillus spores.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Angio-oedema as an unusual tolerable side effect of voriconazole therapy

Gençer

Özer

DEMİRHAN

et al. 2008

Journal of Medical Microbiology

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“…However in immunocompromised or chronically ill persons, a steadily increasing frequency of infection and diversity of infecting mycotic pathogens is apparent [36]. Although there is some overlap between the two groups the most common fungi pathogens isolated from infectious arthritis in healthy hosts residing in endemic regions for dimorphic fungi are Blastomyces dermitidis, Coccidioides spp., and Sporothrix schenkii; whereas in immunocompromised hosts Candida spp., Cryptococcus, and Aspergillus are more often observed.…”

Section: Mycotic Arthritismentioning

confidence: 99%

“…Although there is some overlap between the two groups the most common fungi pathogens isolated from infectious arthritis in healthy hosts residing in endemic regions for dimorphic fungi are Blastomyces dermitidis, Coccidioides spp., and Sporothrix schenkii; whereas in immunocompromised hosts Candida spp., Cryptococcus, and Aspergillus are more often observed. Joint infection in these cases usually results from hematogenous dissemination of the organism [36]. In noncompromised host, infection is typically introduced into joint via trauma or injury, sometimes associated with a penetrating foreign body [37].…”

Section: Mycotic Arthritismentioning

confidence: 99%

Current Concepts on the Etiology and Treatment Of Infectious arthritis

C.Abdullah¹

2014

iosrphr

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“…Other persistent cases may be caused by adjacent infection, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus epidermidis. Other reported cases of osteomyelitis are mycobacterial infections and fungal, these are rare and usually found in patients with weakened of body immunity [5]. …”

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confidence: 99%

Osteomyelitis: Identification and Management

Kumari¹

2016

MOJOR

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ObjectiveOsteomyelitis is a severe inflammation within the bone, bone marrow and surrounding soft tissue, that develops secondary to infection with microbial organisms. The objective of this article is to present an over view regarding the identification and management of osteomyelitis. IntroductionOsteomyelitis is acute and chronic inflammatory process based upon the histopathological finding rather than duration of infection. Osteomyelitis occurring primarily in children and adolescents pathogenic micro-organism cause inflammation and infection of bone, which lead to osteomyelitis and signs appears after two weeks of infection (Figure 1) In chronic osteomyelitis necrotic bone is present and signs may not appear until six weeks of infection [1]. Osteomyelitis infection is based on open wound, haematogenous or direct bacterial inoculation inside bone [2]. Radio nuclides imagine have improved diagnostic accuracy and better orthopaedic techniques as well as use of some prophylactic regimens which help to minimize the risk of infection among osteomyelitis patient. EtiologyBacterial Staphylococcus is common infection which causes an acute and chronic haematogenous osteomyelitis. Different types of pathogens among children are Type A streptococcus, Streptococcus pneumonia, Kingella kingae and Type B streptococcal infection is mainly occur in infants [3]. Streptococcus aureus is the common pathogen in bone among adults. Progressively, methicillinresistant Staphylococcus aureus is separated from patients with osteomyelitis [4]. Other persistent cases may be caused by adjacent infection, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus epidermidis. Other reported cases of osteomyelitis are mycobacterial infections and fungal, these are rare and usually found in patients with weakened of body immunity [5]. PathogenesisOsteomyelitis may be occurring direct inoculation of causative organism in bone. Normal bone is highly resistant to infection occur in case of injury, trauma, and existence of foreign bodies [6]. Causative organism streptococcus aureus adhere to bone and expressing receptors for bone matrix. An insignificant skin infection emerge the serious infection such as sub-acute and acute bacterial endocarditic [7]. In children and adults, osteomyelitis mainly involves metaphysis of long bone, femur, proximal radius and hummers [8,9]. Penetrating injury and surgical contamination are the most common causes of direct inoculation osteomyelitis. Patent with severe vascular diseases often lead to osteomyelitis. Clinical ManifestationOsteomyelitis of acute haematogenous results from bacterial growth of bone. Most of the Children are more prone to infection because of developing of meta-physeal regions of the long bones, rich in blood supply and more prone to slight trauma. Acute haematogenous osteomyelitis in children occur about one-half of all patients who are under five years [10]. Children usually came with the symptom of exist fever, irritability, local erythema, swelling in soft tissues and tenderness bo...

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Fungal Arthritis and Osteomyelitis

Cited by 89 publications

References 66 publications

Angio-oedema as an unusual tolerable side effect of voriconazole therapy

Angio-oedema as an unusual tolerable side effect of voriconazole therapy

Current Concepts on the Etiology and Treatment Of Infectious arthritis

Osteomyelitis: Identification and Management

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