Fundamentals on the molecular mechanism of action of antimicrobial peptides

Corrêa, Jessica Audrey Feijó; Evangelista, Alberto Gonçalves; Nazareth, Tiago de Melo; Luciano, Fernando Bittencourt

doi:10.1016/j.mtla.2019.100494

Cited by 75 publications

(62 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the fact that the phenolic acids found in the CFS have previously been reported as antifungal compounds, the antifungal and antimycotoxigenic effects evidenced in our study could be attributed to the bio-complex obtained by L. plantarum MRS fermentation. This bio-complex could contain other metabolites such as proteins, peptides, and organic acids that are widely known as antifungal compounds but have not been identified in our study [28,33,45]. In other words, it seems that the presence of phenolic acids in the CFS only contributed to enhancing the antifungal activity of the bio-complex.…”

Section: Phenolic Acids Produced By L Plantarum Sppmentioning

confidence: 64%

“…However, authors have shown that the antifungal activity of these compounds alone was too low to fully explain the antifungal activity observed [29,30]. Thus, other metabolites have been studied as the source of antifungal activity such as proteinaceous compounds, fatty acids, phenolic acid, hydrogen peroxide, and bacteriocins [31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Nazareth

Luz

Torrijos

et al. 2019

Toxins

Self Cite

View full text Add to dashboard Cite

Fungal spoilage is an important issue for the food industry, leading to food sensory defects, food waste, economic losses and public health concern through the production of mycotoxins. Concomitantly, the search for safer natural products has gained importance since consumers began to look for less processed and chemically treated foods. In this context, the aim of this study was to evaluate the antifungal and antimycotoxigenic effect of seven strains of Lactobacillus plantarum. Lactic acid bacteria (LAB) were grown on Man Rogosa Sharpe (MRS) broth at 37 °C in anaerobic conditions. After that, the cell-free supernatant (CFS) were recovered to determine its antifungal activity by halo diffusion agar test. In addition, minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) was determined for each L. plantarum CFS by 96-well microplates method. Additionally, CFS was used as a natural biocontrol agent on corn kernels and corn ears contaminated with Aspergillus flavus and Fusarium verticillioides, respectively. The L. plantarum CECT 749 CFS showed the highest antifungal effect against all essayed strains. Moreover, the employment of this CFS in food reduced the mycotoxin production at a percentage ranging from 73.7 to 99.7%. These results suggest that the L. plantarum CECT 749 CFS could be promising for the biocontrol of corn.

show abstract

Section: Phenolic Acids Produced By L Plantarum Sppmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Nazareth

Luz

Torrijos

et al. 2019

Toxins

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, this pore-forming mechanism requires a certain concentration threshold and the required concentration of AMPs is high. Human cathelicidin LL-37 exhibits its activity through this mechanism, and AMPs with β-sheet structure also play a role in this model (Shenkarev et al, 2011;Corrêa et al, 2019). Polarized light-attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) was used to study the effect of AMP cecropin P1 on the bacterial cell membrane and found that it was an applied flat on the surface of the pathogen's cell membrane to destabilize and eventually destroy the cell membrane (Lyu et al, 2019).…”

Section: Carpet-like Modelmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. The emergence of antibiotic-resistant microorganisms and the increasing of concerns about the use of antibiotics resulted in the development of AMPs, which have a good application prospect in medicine, food, animal husbandry, agriculture and aquaculture. This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. The research progress on antivirus peptides, especially anti-coronavirus (COVID-19) peptides, has been introduced given the COVID-19 pandemic worldwide in 2020.

show abstract

“…The biocide access to these regions is determined by the extracellular material, cell morphology and the cellular chemical composition [12][13][14]. According to the mechanisms of antibacterial action, these agents are now divided into the following five main groups whose mechanisms are [13,[15][16][17][18] Interference with cell membrane integrity.…”

mentioning

confidence: 99%

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

2020

View full text Add to dashboard Cite

Besides their positive role, microorganisms are related to a number of undesirable effects, including many diseases, biodeterioration and food spoilage, so when their presence is undesired, they must be controlled. Numerous biocides limiting the development of microorganisms have been proposed, however, in this paper the biocidal and inhibitory activity of quaternary ammonium salts (QASs) and their zwitterionic derivatives is addressed. This paper presents the current state of knowledge about the biocidal activity of QAS and their derivatives. Moreover, the known mechanisms of antimicrobial activity and the problem of emerging resistance to QAS are discussed. The latest trends in the study of surfactants and their potential use are also presented.

show abstract

Fundamentals on the molecular mechanism of action of antimicrobial peptides

Cited by 75 publications

References 185 publications

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

Contact Info

Product

Resources

About