Functions of MVs in Inter-Bacterial Communication

Toyofuku, Masanori; Tashiro, Yosuke; Nomura, Nobuhiko; Eberl, Leo

doi:10.1007/978-3-030-36331-4_5

Cited by 6 publications

(5 citation statements)

References 79 publications

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“…Specific cellular responses may also lead to EV formation, which is particularly important in the context of environmental settings. This is the case for EOMVs, which are EVs formed as a consequence of cell lysis, triggered by phage-derived endolysins that degrade the peptidoglycan, after which the cell rounds up and explodes [ 41 , 73 , 74 ]. This mechanism of EV release has only been observed and reported in Pseudomonas aeruginosa [ 74 ], but is likely to occur in many other Gram-negative bacteria.…”

Section: Evs’ Biogenesismentioning

confidence: 99%

Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria

Lima

Matinha-Cardoso

Tamagnini

et al. 2020

Life

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In bacteria, the active transport of material from the interior to the exterior of the cell, or secretion, represents a very important mechanism of adaptation to the surrounding environment. The secretion of various types of biomolecules is mediated by a series of multiprotein complexes that cross the bacterial membrane(s), each complex dedicated to the secretion of specific substrates. In addition, biological material may also be released from the bacterial cell in the form of vesicles. Extracellular vesicles (EVs) are bilayered, nanoscale structures, derived from the bacterial cell envelope, which contain membrane components as well as soluble products. In cyanobacteria, the knowledge regarding EVs is lagging far behind compared to what is known about, for example, other Gram-negative bacteria. Here, we present a summary of the most important findings regarding EVs in Gram-negative bacteria, discussing aspects of their composition, formation processes and biological roles, and highlighting a number of technological applications tested. This lays the groundwork to raise awareness that the release of EVs by cyanobacteria likely represents an important, and yet highly disregarded, survival strategy. Furthermore, we hope to motivate future studies that can further elucidate the role of EVs in cyanobacterial cell biology and physiology.

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Section: Evs’ Biogenesismentioning

confidence: 99%

Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria

Lima

Matinha-Cardoso

Tamagnini

et al. 2020

Life

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“…104 Conceivably, a single MV containing concentrated QS signals is sufficient to activate QS regulation in the recipient cell. 104,121 Thus, MVs-mediated QS regulation may influence population-wide changes. The association between QS and MVs has not been studied so far in the gut microbiota.…”

Section: Membrane Vesicles-mediated Interactionsmentioning

confidence: 99%

Molecular trafficking between bacteria determines the shape of gut microbial community

2021

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Complex inter-bacterial interactions largely influence the structure and function of the gut microbial community. Though several host-associated phenomena have often been shown to be involved in the stability, structure, and function of the gut microbial community, the implication of contact-dependent and contact-independent inter-bacterial interactions has been overlooked. Such interactions are tightly governed at multiple layers through several extracellular organelles, including contact-dependent inhibition (CDI), nanotubes, type VI secretion system (T6SS), and membrane vesicles (MVs). Recent advancements in molecular techniques have revealed that such extracellular organelles function beyond exhibiting competitive behavior and are also involved in manifesting cooperative behaviors. Cooperation between bacteria occurs through the sharing of several beneficial molecules including nucleic acids, proteins, metabolites, and nutrients among the members of the community, while competition occurs by means of multiple toxins. Intrinsic coordination between contact-dependent and contact-independent mechanisms collectively provides a fitness advantage and increased colonization resistance to the gut microbiota, where molecular trafficking plays a key role. This review is intended to provide a comprehensive view of the salient features of the different bacterial interactions and to highlight how microbiota deploy multifaceted organelles, for exerting both cooperative and competitive behaviors. We discuss the current knowledge of bacterial molecular trafficking and its impact on shaping the gut microbial community.

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“…A more recently discovered mechanism that supports both nutrient sharing and genetic exchanges is the one linked to membrane vesicles. This system also ensures communication between bacterial cells, since, inside the vesicles, different cargo molecules can be transported (nutrients, DNA, and hydrophobic QS peptides) ( Toyofuku et al, 2020 ). Vesicles are present in Gram-negative and Gram-positive bacteria and can originate both in the outer ( Manning and Kuehn, 2011 ) and in the cytoplasmic membrane ( Lee et al, 2009 ).…”

Section: Cooperative Strategies: So Advantageous and So Difficult To mentioning

confidence: 99%

The Less Expensive Choice: Bacterial Strategies to Achieve Successful and Sustainable Reciprocal Interactions

Pessione

2021

Front. Microbiol.

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Bacteria, the first organisms that appeared on Earth, continue to play a central role in ensuring life on the planet, both as biogeochemical agents and as higher organisms’ symbionts. In the last decades, they have been employed both as bioremediation agents for cleaning polluted sites and as bioconversion effectors for obtaining a variety of products from wastes (including eco-friendly plastics and green energies). However, some recent reports suggest that bacterial biodiversity can be negatively affected by the present environmental crisis (global warming, soil desertification, and ocean acidification). This review analyzes the behaviors positively selected by evolution that render bacteria good models of sustainable practices (urgent in these times of climate change and scarcity of resources). Actually, bacteria display a tendency to optimize rather than maximize, to economize energy and building blocks (by using the same molecule for performing multiple functions), and to recycle and share metabolites, and these are winning strategies when dealing with sustainability. Furthermore, their ability to establish successful reciprocal relationships by means of anticipation, collective actions, and cooperation can also constitute an example highlighting how evolutionary selection favors behaviors that can be strategic to contain the present environmental crisis.

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Functions of MVs in Inter-Bacterial Communication

Cited by 6 publications

References 79 publications

Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria

Extracellular Vesicles: An Overlooked Secretion System in Cyanobacteria

Molecular trafficking between bacteria determines the shape of gut microbial community

The Less Expensive Choice: Bacterial Strategies to Achieve Successful and Sustainable Reciprocal Interactions

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